Desquamative interstitial pneumonia following long-term nitrofurantoin therapy

Roger C. Bone, John Wolfe, Richard E. Sobonya, Gerald R. Kerby, Daniel Stechschulte, William E. Ruth, Maura Welch

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46 Scopus citations


Two patients with diffuse interstitial lung disease after long-term nitrofurantoin therapy were characterized clinically by exertional dyspnea and basilar rales, roentgenographically by diffuse interstitial infiltrate and physiologically by a restrictive lung defect. Pathologically, light microscopy revealed desquamative interstitial pneumonia. In one patient electron microscopy was characteristic of desquamative interstitial pneumonia. Immunofluorescent studies of one biopsy specimen showed specific fluorescence of interstitial cells with immunoglobulin E and third component of complement. In in vitro studies, nitrofurantoin therapy failed to induce lymphoblast transformation or histamine release. Treatment consisted of discontinuing the administration of nitrofurantoin and adding corticosteroids. Both patients felt better and showed clinical improvement. Our findings suggest that in some cases desquamative interstitial pneumonia may be drug related.

Original languageEnglish (US)
Pages (from-to)697-701
Number of pages5
JournalThe American journal of medicine
Issue number5
StatePublished - May 10 1976

ASJC Scopus subject areas

  • General Medicine


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