Design, synthesis, and validation of rigid linkers for bioactive peptides

Yasunari Monguchi; Josef Vagner; Heather L. Handl; Umasish Jana; Lucinda J. Begay; Victor J. Hruby; Robert J. Gillies; Eugene A. Mash

doi:10.1016/j.tetlet.2005.08.151

Design, synthesis, and validation of rigid linkers for bioactive peptides

Yasunari Monguchi, Josef Vagner, Heather L. Handl, Umasish Jana, Lucinda J. Begay, Victor J. Hruby, Robert J. Gillies, Eugene A. Mash

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Rigid linkers of variable length were synthesized and used to connect two NDP-α-MSH ligands. The linkers were incorporated by solid-phase synthesis. Biological evaluations indicate that there is virtually no effect of these linkers on ligand binding to the human melanocortin 4 receptor.

Original language	English (US)
Pages (from-to)	7589-7592
Number of pages	4
Journal	Tetrahedron Letters
Volume	46
Issue number	44
DOIs	https://doi.org/10.1016/j.tetlet.2005.08.151
State	Published - Oct 31 2005

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/j.tetlet.2005.08.151

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title = "Design, synthesis, and validation of rigid linkers for bioactive peptides",

abstract = "Rigid linkers of variable length were synthesized and used to connect two NDP-α-MSH ligands. The linkers were incorporated by solid-phase synthesis. Biological evaluations indicate that there is virtually no effect of these linkers on ligand binding to the human melanocortin 4 receptor.",

author = "Yasunari Monguchi and Josef Vagner and Handl, {Heather L.} and Umasish Jana and Begay, {Lucinda J.} and Hruby, {Victor J.} and Gillies, {Robert J.} and Mash, {Eugene A.}",

note = "Funding Information: This work was supported by grants R33 CA 95944 and RO1 CA 97360 from the National Cancer Institute. ",

year = "2005",

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doi = "10.1016/j.tetlet.2005.08.151",

language = "English (US)",

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journal = "Tetrahedron Letters",

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TY - JOUR

T1 - Design, synthesis, and validation of rigid linkers for bioactive peptides

AU - Monguchi, Yasunari

AU - Vagner, Josef

AU - Handl, Heather L.

AU - Jana, Umasish

AU - Begay, Lucinda J.

AU - Hruby, Victor J.

AU - Gillies, Robert J.

AU - Mash, Eugene A.

N1 - Funding Information: This work was supported by grants R33 CA 95944 and RO1 CA 97360 from the National Cancer Institute.

PY - 2005/10/31

Y1 - 2005/10/31

N2 - Rigid linkers of variable length were synthesized and used to connect two NDP-α-MSH ligands. The linkers were incorporated by solid-phase synthesis. Biological evaluations indicate that there is virtually no effect of these linkers on ligand binding to the human melanocortin 4 receptor.

AB - Rigid linkers of variable length were synthesized and used to connect two NDP-α-MSH ligands. The linkers were incorporated by solid-phase synthesis. Biological evaluations indicate that there is virtually no effect of these linkers on ligand binding to the human melanocortin 4 receptor.

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U2 - 10.1016/j.tetlet.2005.08.151

DO - 10.1016/j.tetlet.2005.08.151

M3 - Article

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SN - 0040-4039

VL - 46

SP - 7589

EP - 7592

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 44

ER -

Design, synthesis, and validation of rigid linkers for bioactive peptides

Abstract

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