Rigid linkers of variable length were synthesized and used to connect two NDP-α-MSH ligands. The linkers were incorporated by solid-phase synthesis. Biological evaluations indicate that there is virtually no effect of these linkers on ligand binding to the human melanocortin 4 receptor.
|Original language||English (US)|
|Number of pages||4|
|State||Published - Oct 31 2005|
ASJC Scopus subject areas
- Drug Discovery
- Organic Chemistry