Design, synthesis, and validation of rigid linkers for bioactive peptides

Yasunari Monguchi, Josef Vagner, Heather L. Handl, Umasish Jana, Lucinda J. Begay, Victor J. Hruby, Robert J. Gillies, Eugene A. Mash

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Rigid linkers of variable length were synthesized and used to connect two NDP-α-MSH ligands. The linkers were incorporated by solid-phase synthesis. Biological evaluations indicate that there is virtually no effect of these linkers on ligand binding to the human melanocortin 4 receptor.

Original languageEnglish (US)
Pages (from-to)7589-7592
Number of pages4
JournalTetrahedron Letters
Issue number44
StatePublished - Oct 31 2005

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


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