Design, synthesis, and validation of rigid linkers for bioactive peptides

Yasunari Monguchi; Josef Vagner; Heather L. Handl; Umasish Jana; Lucinda J. Begay; Victor J Hruby; Robert J. Gillies; Eugene A. Mash

doi:10.1016/j.tetlet.2005.08.151

Design, synthesis, and validation of rigid linkers for bioactive peptides

Yasunari Monguchi, Josef Vagner, Heather L. Handl, Umasish Jana, Lucinda J. Begay, Victor J Hruby, Robert J. Gillies, Eugene A. Mash

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Rigid linkers of variable length were synthesized and used to connect two NDP-α-MSH ligands. The linkers were incorporated by solid-phase synthesis. Biological evaluations indicate that there is virtually no effect of these linkers on ligand binding to the human melanocortin 4 receptor.

Original language	English (US)
Pages (from-to)	7589-7592
Number of pages	4
Journal	Tetrahedron Letters
Volume	46
Issue number	44
DOIs	https://doi.org/10.1016/j.tetlet.2005.08.151
State	Published - Oct 31 2005

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

Access to Document

10.1016/j.tetlet.2005.08.151

Cite this

@article{f5a94634a34f4f6f8fca0a49563ef65d,

title = "Design, synthesis, and validation of rigid linkers for bioactive peptides",

abstract = "Rigid linkers of variable length were synthesized and used to connect two NDP-α-MSH ligands. The linkers were incorporated by solid-phase synthesis. Biological evaluations indicate that there is virtually no effect of these linkers on ligand binding to the human melanocortin 4 receptor.",

author = "Yasunari Monguchi and Josef Vagner and Handl, {Heather L.} and Umasish Jana and Begay, {Lucinda J.} and Hruby, {Victor J} and Gillies, {Robert J.} and Mash, {Eugene A.}",

note = "Funding Information: This work was supported by grants R33 CA 95944 and RO1 CA 97360 from the National Cancer Institute. ",

year = "2005",

month = oct,

day = "31",

doi = "10.1016/j.tetlet.2005.08.151",

language = "English (US)",

volume = "46",

pages = "7589--7592",

journal = "Tetrahedron Letters",

issn = "0040-4039",

publisher = "Elsevier Ltd",

number = "44",

}

TY - JOUR

T1 - Design, synthesis, and validation of rigid linkers for bioactive peptides

AU - Monguchi, Yasunari

AU - Vagner, Josef

AU - Handl, Heather L.

AU - Jana, Umasish

AU - Begay, Lucinda J.

AU - Hruby, Victor J

AU - Gillies, Robert J.

AU - Mash, Eugene A.

N1 - Funding Information: This work was supported by grants R33 CA 95944 and RO1 CA 97360 from the National Cancer Institute.

PY - 2005/10/31

Y1 - 2005/10/31

N2 - Rigid linkers of variable length were synthesized and used to connect two NDP-α-MSH ligands. The linkers were incorporated by solid-phase synthesis. Biological evaluations indicate that there is virtually no effect of these linkers on ligand binding to the human melanocortin 4 receptor.

AB - Rigid linkers of variable length were synthesized and used to connect two NDP-α-MSH ligands. The linkers were incorporated by solid-phase synthesis. Biological evaluations indicate that there is virtually no effect of these linkers on ligand binding to the human melanocortin 4 receptor.

UR - http://www.scopus.com/inward/record.url?scp=26244439921&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=26244439921&partnerID=8YFLogxK

U2 - 10.1016/j.tetlet.2005.08.151

DO - 10.1016/j.tetlet.2005.08.151

M3 - Article

AN - SCOPUS:26244439921

SN - 0040-4039

VL - 46

SP - 7589

EP - 7592

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 44

ER -

Design, synthesis, and validation of rigid linkers for bioactive peptides

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this