Design, synthesis, and validation of a branched flexible linker for bioactive peptides

Martina E. Bowen; Yasunari Monguchi; Rajesh Sankaranarayanan; Josef Vagner; Lucinda J. Begay; Liping Xu; Bhumasamudram Jagadish; Victor J. Hruby; Robert J. Gillies; Eugene A. Mash

doi:10.1021/jo062276g

Design, synthesis, and validation of a branched flexible linker for bioactive peptides

Martina E. Bowen, Yasunari Monguchi, Rajesh Sankaranarayanan, Josef Vagner, Lucinda J. Begay, Liping Xu, Bhumasamudram Jagadish, Victor J. Hruby, Robert J. Gillies, Eugene A. Mash

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

A branched flexible linker that incorporates a fluorescent dansyl moiety was synthesized and used to connect two high affinity NDP-α-MSH ligands or two low affinity MSH(4) ligands. The linker was incorporated into the conjugate by solid-phase synthesis. In vitro biological evaluations showed that potency of binding to the human melanocortin 4 receptor was not diminished for linker-ligand combinations relative to the corresponding ligand alone.

Original language	English (US)
Pages (from-to)	1675-1680
Number of pages	6
Journal	Journal of Organic Chemistry
Volume	72
Issue number	5
DOIs	https://doi.org/10.1021/jo062276g
State	Published - Mar 2 2007

ASJC Scopus subject areas

Organic Chemistry

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10.1021/jo062276g

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Design, synthesis, and validation of a branched flexible linker for bioactive peptides. / Bowen, Martina E.; Monguchi, Yasunari; Sankaranarayanan, Rajesh; Vagner, Josef; Begay, Lucinda J.; Xu, Liping; Jagadish, Bhumasamudram; Hruby, Victor J.; Gillies, Robert J.; Mash, Eugene A.

In: Journal of Organic Chemistry, Vol. 72, No. 5, 02.03.2007, p. 1675-1680.

Research output: Contribution to journal › Article › peer-review

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AU - Monguchi, Yasunari

AU - Sankaranarayanan, Rajesh

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AU - Begay, Lucinda J.

AU - Xu, Liping

AU - Jagadish, Bhumasamudram

AU - Hruby, Victor J.

AU - Gillies, Robert J.

AU - Mash, Eugene A.

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Design, synthesis, and validation of a branched flexible linker for bioactive peptides

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