Abstract
A branched flexible linker that incorporates a fluorescent dansyl moiety was synthesized and used to connect two high affinity NDP-α-MSH ligands or two low affinity MSH(4) ligands. The linker was incorporated into the conjugate by solid-phase synthesis. In vitro biological evaluations showed that potency of binding to the human melanocortin 4 receptor was not diminished for linker-ligand combinations relative to the corresponding ligand alone.
Original language | English (US) |
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Pages (from-to) | 1675-1680 |
Number of pages | 6 |
Journal | Journal of Organic Chemistry |
Volume | 72 |
Issue number | 5 |
DOIs | |
State | Published - Mar 2 2007 |
ASJC Scopus subject areas
- Organic Chemistry