Design of new topoisomerase II inhibitors based upon a quinobenzoxazine self-assembly model

Qingping Zeng; Yan Kwok; Sean M. Kerwin; Gina Mangold; Laurence H. Hurley

doi:10.1021/jm980265c

Design of new topoisomerase II inhibitors based upon a quinobenzoxazine self-assembly model

Qingping Zeng, Yan Kwok, Sean M. Kerwin, Gina Mangold, Laurence H. Hurley

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Abstract

A new class of pyridobenzophenoxazine compounds has been developed as topoisomerase II inhibitors for anticancer chemotherapy. These compounds were designed based on a proposed model of a quinobenzoxazine self-assembly complex on DNA. They showed excellent inhibitory effects on several tumor cell lines with nanomolar IC₅₀ values. Their cytotoxic potency correlates with theft ability to unwind DNA and inhibit topoisomerase II.

Original language	English (US)
Pages (from-to)	4273-4278
Number of pages	6
Journal	Journal of Medicinal Chemistry
Volume	41
Issue number	22
DOIs	https://doi.org/10.1021/jm980265c
State	Published - Oct 23 1998
Externally published	Yes

ASJC Scopus subject areas

Molecular Medicine
Drug Discovery

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10.1021/jm980265c

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title = "Design of new topoisomerase II inhibitors based upon a quinobenzoxazine self-assembly model",

abstract = "A new class of pyridobenzophenoxazine compounds has been developed as topoisomerase II inhibitors for anticancer chemotherapy. These compounds were designed based on a proposed model of a quinobenzoxazine self-assembly complex on DNA. They showed excellent inhibitory effects on several tumor cell lines with nanomolar IC50 values. Their cytotoxic potency correlates with theft ability to unwind DNA and inhibit topoisomerase II.",

author = "Qingping Zeng and Yan Kwok and Kerwin, {Sean M.} and Gina Mangold and Hurley, {Laurence H.}",

year = "1998",

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T1 - Design of new topoisomerase II inhibitors based upon a quinobenzoxazine self-assembly model

AU - Zeng, Qingping

AU - Kwok, Yan

AU - Kerwin, Sean M.

AU - Mangold, Gina

AU - Hurley, Laurence H.

PY - 1998/10/23

Y1 - 1998/10/23

N2 - A new class of pyridobenzophenoxazine compounds has been developed as topoisomerase II inhibitors for anticancer chemotherapy. These compounds were designed based on a proposed model of a quinobenzoxazine self-assembly complex on DNA. They showed excellent inhibitory effects on several tumor cell lines with nanomolar IC50 values. Their cytotoxic potency correlates with theft ability to unwind DNA and inhibit topoisomerase II.

AB - A new class of pyridobenzophenoxazine compounds has been developed as topoisomerase II inhibitors for anticancer chemotherapy. These compounds were designed based on a proposed model of a quinobenzoxazine self-assembly complex on DNA. They showed excellent inhibitory effects on several tumor cell lines with nanomolar IC50 values. Their cytotoxic potency correlates with theft ability to unwind DNA and inhibit topoisomerase II.

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Design of new topoisomerase II inhibitors based upon a quinobenzoxazine self-assembly model

Abstract

ASJC Scopus subject areas

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