Design of emission ratiometric metal-ion sensors with enhanced two-photon cross section and brightness

S. Sumalekshmy, Maged M. Henary, Nisan Siegel, Pa Dreyia V. Lawson, Yonggang Wu, Karin Schmidt, Jean Luc Brédas, Joseph W. Perry, Christoph J. Fahrni

Research output: Contribution to journalArticlepeer-review

112 Scopus citations

Abstract

To develop metal-responsive fluorescence probes with optimized nonlinear optical properties for two-photon excitation fluorescence microscopy (TPEM), we investigated the utility of donor-acceptor architectures where the metal-ion coordinates to the acceptor rather than donor site of the fluorophore. Zn(II) binding to such a probe consisting of a tris(picolyl)amine-substituted acceptor site connected with an anisole donor moiety and an oxazole central core resulted in a significant increase of the two-photon absorption cross section (δ) and fluorescence brightness (ηδ). The fluorophore showed also a strong shift of the emission peak upon saturation with Zn(II), rendering the proposed approach suitable for two-photon excited emission ratiometric sensing.

Original languageEnglish (US)
Pages (from-to)11888-11889
Number of pages2
JournalJournal of the American Chemical Society
Volume129
Issue number39
DOIs
StatePublished - Oct 3 2007
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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