@inproceedings{d42f09b412984ac8aeeb0fe9691bd0c6,
title = "Design of an in-vivo multi-spectral confocal microendoscope for clinical trials",
abstract = "We previously reported on the development and testing of a multi-spectral confocal microendoscope. Here we present a new system that will be used during an early stage clinical trial. The new microendoscope is significantly smaller, uses fewer optical elements, and is structurally more robust. The slit-scanning confocal system employs two synchronized single-axes scan mirrors and an externally coupled imaging catheter with automated focus control and dye delivery systems. In grayscale collection mode the confocal microendoscope operates at 30 frames-per-second with 3μm lateral resolution and 25μm axial resolution. The multi-spectral collection mode operates at 0.5 frames-per-second when acquiring 32 spectral channels with an average minimum resolvable wavelength difference of 12nm. The system will be used, in grayscale mode, to image ovaries during a small scale clinical trial on women undergoing oophorectomy. Recent grayscale and multi-spectral imaging results from ex-vivo human tissues are presented.",
keywords = "Confocal, Endoscope, Fiber, Fluorescence, Microscopy, Optics, Spectral, Spectroscopy, Tissue",
author = "Rouse, {Andrew R.} and Tanbakuchi, {Anthony A.} and Udovich, {Joshua A.} and Gmitro, {Arthur F.}",
year = "2006",
doi = "10.1117/12.646913",
language = "English (US)",
isbn = "0819461245",
series = "Proceedings of SPIE - The International Society for Optical Engineering",
booktitle = "Proceedings of SPIE - The International Society for Optical Engineering",
note = "Endoscopic Microscopy ; Conference date: 22-01-2006 Through 22-01-2006",
}