Design of affinity membrane chromatographic columns

A. Tejeda-Mansir; J. M. Juvera; I. Magaña; R. Guzmán

doi:10.1007/s004490050491

Design of affinity membrane chromatographic columns

A. Tejeda-Mansir, J. M. Juvera, I. Magaña, R. Guzmán

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

A method for affinity membrane column design, based on the analytical solution of the Thomas model for frontal analysis in membrane column adsorption, was developed. The method permits to find the operating conditions to reach a 93.5% of the column capacity as operating capacity, using a sharpness restriction for the system breakthrough curve. The solution of the model is presented in a graphic form and can be used in a wide range of operational conditions, provided that four design restrictions are fulfilled. The application of the method was illustrated using experimental data and a simple procedure. The implications of the results on the design and optimization of affinity membrane chromatographic columns are discussed.

Original language	English (US)
Pages (from-to)	115-119
Number of pages	5
Journal	Bioprocess Engineering
Volume	19
Issue number	2
DOIs	https://doi.org/10.1007/s004490050491
State	Published - 1998

ASJC Scopus subject areas

Biotechnology
Applied Microbiology and Biotechnology

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10.1007/s004490050491

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title = "Design of affinity membrane chromatographic columns",

abstract = "A method for affinity membrane column design, based on the analytical solution of the Thomas model for frontal analysis in membrane column adsorption, was developed. The method permits to find the operating conditions to reach a 93.5% of the column capacity as operating capacity, using a sharpness restriction for the system breakthrough curve. The solution of the model is presented in a graphic form and can be used in a wide range of operational conditions, provided that four design restrictions are fulfilled. The application of the method was illustrated using experimental data and a simple procedure. The implications of the results on the design and optimization of affinity membrane chromatographic columns are discussed.",

author = "A. Tejeda-Mansir and Juvera, {J. M.} and I. Maga{\~n}a and R. Guzm{\'a}n",

note = "Funding Information: This work was supported in part by a grant from Universidad de Sonora-University of Arizona international cooperation agreement.",

year = "1998",

doi = "10.1007/s004490050491",

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pages = "115--119",

journal = "Bioprocess Engineering",

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TY - JOUR

T1 - Design of affinity membrane chromatographic columns

AU - Tejeda-Mansir, A.

AU - Juvera, J. M.

AU - Magaña, I.

AU - Guzmán, R.

N1 - Funding Information: This work was supported in part by a grant from Universidad de Sonora-University of Arizona international cooperation agreement.

PY - 1998

Y1 - 1998

N2 - A method for affinity membrane column design, based on the analytical solution of the Thomas model for frontal analysis in membrane column adsorption, was developed. The method permits to find the operating conditions to reach a 93.5% of the column capacity as operating capacity, using a sharpness restriction for the system breakthrough curve. The solution of the model is presented in a graphic form and can be used in a wide range of operational conditions, provided that four design restrictions are fulfilled. The application of the method was illustrated using experimental data and a simple procedure. The implications of the results on the design and optimization of affinity membrane chromatographic columns are discussed.

AB - A method for affinity membrane column design, based on the analytical solution of the Thomas model for frontal analysis in membrane column adsorption, was developed. The method permits to find the operating conditions to reach a 93.5% of the column capacity as operating capacity, using a sharpness restriction for the system breakthrough curve. The solution of the model is presented in a graphic form and can be used in a wide range of operational conditions, provided that four design restrictions are fulfilled. The application of the method was illustrated using experimental data and a simple procedure. The implications of the results on the design and optimization of affinity membrane chromatographic columns are discussed.

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JO - Bioprocess Engineering

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Design of affinity membrane chromatographic columns

Abstract

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