Design and implementation of a portable colposcope Mueller matrix polarimeter

Mariacarla Gonzalez, Karla Alejandra Montejo, Karl Krupp, Vijaya Srinivas, Edward Dehoog, Purnima Madhivanan, Jessica C. Ramella-Roman

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Significance: Mueller matrix polarimetry can provide useful information about the function and structure of the extracellular matrix. A portable and low-cost system could facilitate the clinical assessment of cervical anomalies in low-resource settings. Aim: We introduce a low-cost snapshot Mueller matrix polarimeter that does not require external power, has no moving parts, and can acquire a full Mueller matrix in a 1/41 s, to conduct a feasibility study for cervical imaging in the low-resource setting. Approach: A snapshot system based on two sets of Savart plates, a ring illuminator with polarizing elements (generating four polarization states), and one camera is introduced. Stokes vectors are formulated to recover the polarization properties of the sample. Then, using Mueller matrix decomposition, the depolarization and retardance information is extracted. Results: We report the results on 16 healthy individuals (out of 22 patients imaged), whose Pap smear showed no malignant findings from mobile clinics in rural region of Mysore, India. The depolarization and retardance information was in agreement with previous reports. Conclusions: We introduce an imaging system and conducted a feasibility study on healthy individuals. This work could futurely translate into diagnostic applications to provide a quantitative platform in the clinical environment (e.g., cervical cancer screening).

Original languageEnglish (US)
Article number116006
JournalJournal of biomedical optics
Volume25
Issue number11
DOIs
StatePublished - Nov 1 2020

Keywords

  • collagen
  • colposcopy
  • Mueller matrix
  • polarimetry

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Biomedical Engineering

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