Abstract
After chronic exposure to neurokinin A, a time-dependent and recoverable desensitization of inositol monophosphate accumulation occurred in B82 fibroblasts transfected with cDNAs encoding for the bovine stomach NK2 receptor. Desensitized cells also showed decreased Ca2+ mobilization. While NK2 receptor antagonists had no effect on inositol monophosphate accumulation, substance P and senktide both produced a small degree of desensitization.
Original language | English (US) |
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Pages (from-to) | 75-78 |
Number of pages | 4 |
Journal | European Journal of Pharmacology: Molecular Pharmacology |
Volume | 245 |
Issue number | 1 |
DOIs | |
State | Published - Mar 15 1993 |
Keywords
- Desensitization
- NK receptors
- Neurokinin A
ASJC Scopus subject areas
- Pharmacology