After chronic exposure to neurokinin A, a time-dependent and recoverable desensitization of inositol monophosphate accumulation occurred in B82 fibroblasts transfected with cDNAs encoding for the bovine stomach NK2 receptor. Desensitized cells also showed decreased Ca2+ mobilization. While NK2 receptor antagonists had no effect on inositol monophosphate accumulation, substance P and senktide both produced a small degree of desensitization.
|Original language||English (US)|
|Number of pages||4|
|Journal||European Journal of Pharmacology: Molecular Pharmacology|
|State||Published - Mar 15 1993|
- NK receptors
- Neurokinin A
ASJC Scopus subject areas