Desensitization of neurokinin A receptors expressed by B82 fibroblasts

Alden K. Henderson; William R. Roeske; Thomas L. Smith; Henry I. Yamamura

doi:10.1016/0922-4106(93)90172-6

Desensitization of neurokinin A receptors expressed by B82 fibroblasts

Alden K. Henderson, William R. Roeske, Thomas L. Smith, Henry I. Yamamura

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

After chronic exposure to neurokinin A, a time-dependent and recoverable desensitization of inositol monophosphate accumulation occurred in B82 fibroblasts transfected with cDNAs encoding for the bovine stomach NK₂ receptor. Desensitized cells also showed decreased Ca²⁺ mobilization. While NK₂ receptor antagonists had no effect on inositol monophosphate accumulation, substance P and senktide both produced a small degree of desensitization.

Original language	English (US)
Pages (from-to)	75-78
Number of pages	4
Journal	European Journal of Pharmacology: Molecular Pharmacology
Volume	245
Issue number	1
DOIs	https://doi.org/10.1016/0922-4106(93)90172-6
State	Published - Mar 15 1993

Keywords

Desensitization
NK receptors
Neurokinin A

ASJC Scopus subject areas

Pharmacology

Access to Document

10.1016/0922-4106(93)90172-6

Cite this

@article{f58fbcef7ed9412192fb1d6d680a3574,

title = "Desensitization of neurokinin A receptors expressed by B82 fibroblasts",

abstract = "After chronic exposure to neurokinin A, a time-dependent and recoverable desensitization of inositol monophosphate accumulation occurred in B82 fibroblasts transfected with cDNAs encoding for the bovine stomach NK2 receptor. Desensitized cells also showed decreased Ca2+ mobilization. While NK2 receptor antagonists had no effect on inositol monophosphate accumulation, substance P and senktide both produced a small degree of desensitization.",

keywords = "Desensitization, NK receptors, Neurokinin A",

author = "Henderson, {Alden K.} and Roeske, {William R.} and Smith, {Thomas L.} and Yamamura, {Henry I.}",

year = "1993",

month = mar,

day = "15",

doi = "10.1016/0922-4106(93)90172-6",

language = "English (US)",

volume = "245",

pages = "75--78",

journal = "European Journal of Pharmacology: Molecular Pharmacology",

issn = "0922-4106",

publisher = "Elsevier B.V.",

number = "1",

}

TY - JOUR

T1 - Desensitization of neurokinin A receptors expressed by B82 fibroblasts

AU - Henderson, Alden K.

AU - Roeske, William R.

AU - Smith, Thomas L.

AU - Yamamura, Henry I.

PY - 1993/3/15

Y1 - 1993/3/15

N2 - After chronic exposure to neurokinin A, a time-dependent and recoverable desensitization of inositol monophosphate accumulation occurred in B82 fibroblasts transfected with cDNAs encoding for the bovine stomach NK2 receptor. Desensitized cells also showed decreased Ca2+ mobilization. While NK2 receptor antagonists had no effect on inositol monophosphate accumulation, substance P and senktide both produced a small degree of desensitization.

AB - After chronic exposure to neurokinin A, a time-dependent and recoverable desensitization of inositol monophosphate accumulation occurred in B82 fibroblasts transfected with cDNAs encoding for the bovine stomach NK2 receptor. Desensitized cells also showed decreased Ca2+ mobilization. While NK2 receptor antagonists had no effect on inositol monophosphate accumulation, substance P and senktide both produced a small degree of desensitization.

KW - Desensitization

KW - NK receptors

KW - Neurokinin A

UR - http://www.scopus.com/inward/record.url?scp=0027512201&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027512201&partnerID=8YFLogxK

U2 - 10.1016/0922-4106(93)90172-6

DO - 10.1016/0922-4106(93)90172-6

M3 - Article

C2 - 8386670

AN - SCOPUS:0027512201

SN - 0922-4106

VL - 245

SP - 75

EP - 78

JO - European Journal of Pharmacology: Molecular Pharmacology

JF - European Journal of Pharmacology: Molecular Pharmacology

IS - 1

ER -

Desensitization of neurokinin A receptors expressed by B82 fibroblasts

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this