Desensitization of neurokinin A receptors expressed by B82 fibroblasts

Alden K. Henderson; William R. Roeske; Thomas L. Smith; Henry I. Yamamura

doi:10.1016/0922-4106(93)90172-6

Desensitization of neurokinin A receptors expressed by B82 fibroblasts

Alden K. Henderson, William R. Roeske, Thomas L. Smith, Henry I. Yamamura

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

After chronic exposure to neurokinin A, a time-dependent and recoverable desensitization of inositol monophosphate accumulation occurred in B82 fibroblasts transfected with cDNAs encoding for the bovine stomach NK₂ receptor. Desensitized cells also showed decreased Ca²⁺ mobilization. While NK₂ receptor antagonists had no effect on inositol monophosphate accumulation, substance P and senktide both produced a small degree of desensitization.

Original language	English (US)
Pages (from-to)	75-78
Number of pages	4
Journal	European Journal of Pharmacology: Molecular Pharmacology
Volume	245
Issue number	1
DOIs	https://doi.org/10.1016/0922-4106(93)90172-6
State	Published - Mar 15 1993

Keywords

Desensitization
NK receptors
Neurokinin A

ASJC Scopus subject areas

Pharmacology

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10.1016/0922-4106(93)90172-6

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abstract = "After chronic exposure to neurokinin A, a time-dependent and recoverable desensitization of inositol monophosphate accumulation occurred in B82 fibroblasts transfected with cDNAs encoding for the bovine stomach NK2 receptor. Desensitized cells also showed decreased Ca2+ mobilization. While NK2 receptor antagonists had no effect on inositol monophosphate accumulation, substance P and senktide both produced a small degree of desensitization.",

keywords = "Desensitization, NK receptors, Neurokinin A",

author = "Henderson, {Alden K.} and Roeske, {William R.} and Smith, {Thomas L.} and Yamamura, {Henry I.}",

year = "1993",

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AU - Henderson, Alden K.

AU - Roeske, William R.

AU - Smith, Thomas L.

AU - Yamamura, Henry I.

PY - 1993/3/15

Y1 - 1993/3/15

N2 - After chronic exposure to neurokinin A, a time-dependent and recoverable desensitization of inositol monophosphate accumulation occurred in B82 fibroblasts transfected with cDNAs encoding for the bovine stomach NK2 receptor. Desensitized cells also showed decreased Ca2+ mobilization. While NK2 receptor antagonists had no effect on inositol monophosphate accumulation, substance P and senktide both produced a small degree of desensitization.

AB - After chronic exposure to neurokinin A, a time-dependent and recoverable desensitization of inositol monophosphate accumulation occurred in B82 fibroblasts transfected with cDNAs encoding for the bovine stomach NK2 receptor. Desensitized cells also showed decreased Ca2+ mobilization. While NK2 receptor antagonists had no effect on inositol monophosphate accumulation, substance P and senktide both produced a small degree of desensitization.

KW - Desensitization

KW - NK receptors

KW - Neurokinin A

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JF - European Journal of Pharmacology - Molecular Pharmacology Section

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Desensitization of neurokinin A receptors expressed by B82 fibroblasts

Abstract

Keywords

ASJC Scopus subject areas

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