TY - JOUR
T1 - (Des-Histidine1) (Nϵ-phenylthiocarbamoyllysine12)-glucagon
T2 - Effects on glycogenolysis in perfused rat liver
AU - Khan, B. A.
AU - Bregman, Marvin D.
AU - Nugent, C. A.
AU - Hruby, Victor J.
AU - Brendel, K.
PY - 1980/4/14
Y1 - 1980/4/14
N2 - (Des-Histidine1) (Nε{lunate}-phenylthiocarbamoyllysine12)-glucagon, synthesized by the one-step Edman degradation procedure is a competitive inhibitor of glucagon action in the rat liver plasma membrane adenylate cyclase system. However, in the perfused rat liver, the compound did not inhibit glucagon stimulated glycogenolysis even when used at a concentration 100-fold in excess of native glucagon. Instead, it showed a weak potency, but full agonist activity, stimulating liver glycogenolysis to 100% of the level obtained by glucagon. These results are discussed in terms of the possible mechanism(s) of glucagon action.
AB - (Des-Histidine1) (Nε{lunate}-phenylthiocarbamoyllysine12)-glucagon, synthesized by the one-step Edman degradation procedure is a competitive inhibitor of glucagon action in the rat liver plasma membrane adenylate cyclase system. However, in the perfused rat liver, the compound did not inhibit glucagon stimulated glycogenolysis even when used at a concentration 100-fold in excess of native glucagon. Instead, it showed a weak potency, but full agonist activity, stimulating liver glycogenolysis to 100% of the level obtained by glucagon. These results are discussed in terms of the possible mechanism(s) of glucagon action.
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U2 - 10.1016/0006-291X(80)91138-9
DO - 10.1016/0006-291X(80)91138-9
M3 - Article
C2 - 7387671
AN - SCOPUS:0018947495
SN - 0006-291X
VL - 93
SP - 729
EP - 736
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 3
ER -