Dendrimer type bio-reducible polymer for efficient gene delivery

Hye Yeong Nam, Kihoon Nam, Minhyung Lee, Sung Wan Kim, David A. Bull

Research output: Contribution to journalArticlepeer-review

62 Scopus citations

Abstract

Arginine-grafted bio-reducible poly(disulfide amine) (ABP) was incorporated into the poly(amido amine) (PAMAM) dendrimer, creating a high molecular weight bio-reducible polymer, PAM-ABP, to overcome the limitations of the low molecular weight ABP. The newly synthesized PAM-ABP was studied to determine its efficacy as a gene delivery carrier. The PAM-ABP demonstrated superior condensing ability for plasmid DNA through the formation of compact nanosized polyplexes. These compact polyplexes enhanced cellular uptake and were less susceptible to reducing agents, resulting in greater transfection efficiency compared to ABP alone. Based on these results, this newly developed PAM-ABP polyplex is a promising delivery system for clinical gene therapy.

Original languageEnglish (US)
Pages (from-to)592-600
Number of pages9
JournalJournal of Controlled Release
Volume160
Issue number3
DOIs
StatePublished - Jun 28 2012
Externally publishedYes

Keywords

  • Bioreducible polymer
  • Cytotoxicity
  • Dendrimer
  • Gene delivery
  • Transfection

ASJC Scopus subject areas

  • Pharmaceutical Science

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