Demultiplexing of Projection Data in Adaptive Brain SPECT with Multi-Pinhole Collimation

Navid Zeraatkar, Kesava S. Kalluri, Benjamin Auer, Neil C. Momsen, Micaehla May, R. Garrett Richards, Lars R. Furenlid, Phillip H. Kuo, Michael A. King

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Scopus citations

Abstract

Multiplexing of projection images is a potential solution to increasing detection sensitivity in multi-pinhole (MPH) SPECT systems. However, the ambiguity caused by overlapped projections can generate artefacts in the reconstructed images. Therefore, multiplexing has been generally avoided in MPH SPECT systems at the cost of sensitivity loss. We are developing a new-generation brain-dedicated stationary SPECT scanner, AdaptiSPECT-C. In this study, we employed a prototype design of the AdaptiSPECT-C consisting of 25 square detectors arranged in a truncated spherical geometry. Each detector is equipped with an MPH collimator having 5 pinhole apertures. Each aperture can be independently opened or closed utilizing a shuttering mechanism. There is intentionally a significant amount of multiplexing when multiple apertures are opened. In this study, we propose an innovative approach to demultiplex projection data from multiple pinholes in the AdaptiSPECT-C. We used our MPH analytic simulation and iterative reconstruction software to investigate two acquisition schemes for an XCAT phantom emulating Nisopropyl-p-(I-123)iodoamphetamine (I-123-IMP) brain-perfusion agent distribution. In this approach, a small portion of imaging time (herein, 20%) is used for acquiring a set of non-multiplexed data by opening only central pinholes in each MPH collimator. The proposed algorithm can then demultiplex the projections acquired thereafter using an estimate of the activity distribution reconstructed from the non-multiplexed data. The results are promising for demultiplexing the projections when compared with simulated non-multiplexed ground truth. We expect this demultiplexing will result in substantial enhancement of the reconstructed images. This and variations in the acquisition schemes will be explored in our future studies.

Original languageEnglish (US)
Title of host publication2020 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2020
PublisherInstitute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)9781728176932
DOIs
StatePublished - 2020
Event2020 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2020 - Boston, United States
Duration: Oct 31 2020Nov 7 2020

Publication series

Name2020 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2020

Conference

Conference2020 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2020
Country/TerritoryUnited States
CityBoston
Period10/31/2011/7/20

Keywords

  • AdaptiSPECT-C
  • Adaptive imaging
  • Brain SPECT
  • Demultiplexing
  • Multi-pinhole
  • Multiplexing

ASJC Scopus subject areas

  • Signal Processing
  • Radiology Nuclear Medicine and imaging
  • Nuclear and High Energy Physics

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