Demonstration of a sucrose-derived contrast agent for magnetic resonance imaging of the GI tract

Gary V. Martinez; Suryakiran Navath; Kamini Sewda; Venkataramanarao Rao; Parastou Foroutan; Ramesh Alleti; Valerie E. Moberg; Ali M. Ahad; Domenico Coppola; Mark C. Lloyd; Robert J. Gillies; David L. Morse; Eugene A. Mash

doi:10.1016/j.bmcl.2013.02.008

Demonstration of a sucrose-derived contrast agent for magnetic resonance imaging of the GI tract

Gary V. Martinez
, Suryakiran Navath
, Kamini Sewda
, Venkataramanarao Rao
, Parastou Foroutan
, Ramesh Alleti
, Valerie E. Moberg
, Ali M. Ahad
, Domenico Coppola
, Mark C. Lloyd
, Robert J. Gillies
, David L. Morse
, Eugene A. Mash

Chemistry & Biochemistry - Sci

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

A scaffold bearing eight terminal alkyne groups was synthesized from sucrose, and copies of an azide-terminated Gd-DOTA complex were attached via copper(I)-catalyzed azide-alkyne cycloaddition. The resulting contrast agent (CA) was administered by gavage to C3H mice. Passage of the CA through the gastrointestinal (GI) tract was followed by T₁-weighted magnetic resonance imaging (MRI) over a period of 47 h, by which time the CA had exited the GI tract. No evidence for leakage of the CA from the GI tract was observed. Thus, a new, orally administered CA for MRI of the GI tract has been developed and successfully demonstrated.

Original language	English (US)
Pages (from-to)	2061-2064
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	23
Issue number	7
DOIs	https://doi.org/10.1016/j.bmcl.2013.02.008
State	Published - Apr 1 2013

Keywords

Contrast agent
DOTA
Gadolinium
Gastrointestinal tract
Magnetic resonance imaging

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/j.bmcl.2013.02.008

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Martinez, G. V., Navath, S., Sewda, K., Rao, V., Foroutan, P., Alleti, R., Moberg, V. E., Ahad, A. M., Coppola, D., Lloyd, M. C., Gillies, R. J., Morse, D. L., & Mash, E. A. (2013). Demonstration of a sucrose-derived contrast agent for magnetic resonance imaging of the GI tract. Bioorganic and Medicinal Chemistry Letters, 23(7), 2061-2064. https://doi.org/10.1016/j.bmcl.2013.02.008

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title = "Demonstration of a sucrose-derived contrast agent for magnetic resonance imaging of the GI tract",

abstract = "A scaffold bearing eight terminal alkyne groups was synthesized from sucrose, and copies of an azide-terminated Gd-DOTA complex were attached via copper(I)-catalyzed azide-alkyne cycloaddition. The resulting contrast agent (CA) was administered by gavage to C3H mice. Passage of the CA through the gastrointestinal (GI) tract was followed by T1-weighted magnetic resonance imaging (MRI) over a period of 47 h, by which time the CA had exited the GI tract. No evidence for leakage of the CA from the GI tract was observed. Thus, a new, orally administered CA for MRI of the GI tract has been developed and successfully demonstrated.",

keywords = "Contrast agent, DOTA, Gadolinium, Gastrointestinal tract, Magnetic resonance imaging",

author = "Martinez, \{Gary V.\} and Suryakiran Navath and Kamini Sewda and Venkataramanarao Rao and Parastou Foroutan and Ramesh Alleti and Moberg, \{Valerie E.\} and Ahad, \{Ali M.\} and Domenico Coppola and Lloyd, \{Mark C.\} and Gillies, \{Robert J.\} and Morse, \{David L.\} and Mash, \{Eugene A.\}",

note = "Funding Information: This work was supported by Grants R33 CA 95944 , RO1 CA 97360 , RO1 CA 123547 , and P30 CA 23074 from the National Cancer Institute . ",

year = "2013",

month = apr,

day = "1",

doi = "10.1016/j.bmcl.2013.02.008",

language = "English (US)",

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pages = "2061--2064",

journal = "Bioorganic and Medicinal Chemistry Letters",

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AU - Martinez, Gary V.

AU - Navath, Suryakiran

AU - Sewda, Kamini

AU - Rao, Venkataramanarao

AU - Foroutan, Parastou

AU - Alleti, Ramesh

AU - Moberg, Valerie E.

AU - Ahad, Ali M.

AU - Coppola, Domenico

AU - Lloyd, Mark C.

AU - Gillies, Robert J.

AU - Morse, David L.

AU - Mash, Eugene A.

N1 - Funding Information: This work was supported by Grants R33 CA 95944 , RO1 CA 97360 , RO1 CA 123547 , and P30 CA 23074 from the National Cancer Institute .

PY - 2013/4/1

Y1 - 2013/4/1

N2 - A scaffold bearing eight terminal alkyne groups was synthesized from sucrose, and copies of an azide-terminated Gd-DOTA complex were attached via copper(I)-catalyzed azide-alkyne cycloaddition. The resulting contrast agent (CA) was administered by gavage to C3H mice. Passage of the CA through the gastrointestinal (GI) tract was followed by T1-weighted magnetic resonance imaging (MRI) over a period of 47 h, by which time the CA had exited the GI tract. No evidence for leakage of the CA from the GI tract was observed. Thus, a new, orally administered CA for MRI of the GI tract has been developed and successfully demonstrated.

AB - A scaffold bearing eight terminal alkyne groups was synthesized from sucrose, and copies of an azide-terminated Gd-DOTA complex were attached via copper(I)-catalyzed azide-alkyne cycloaddition. The resulting contrast agent (CA) was administered by gavage to C3H mice. Passage of the CA through the gastrointestinal (GI) tract was followed by T1-weighted magnetic resonance imaging (MRI) over a period of 47 h, by which time the CA had exited the GI tract. No evidence for leakage of the CA from the GI tract was observed. Thus, a new, orally administered CA for MRI of the GI tract has been developed and successfully demonstrated.

KW - Contrast agent

KW - DOTA

KW - Gadolinium

KW - Gastrointestinal tract

KW - Magnetic resonance imaging

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M3 - Article

C2 - 23481651

AN - SCOPUS:84875214927

SN - 0960-894X

VL - 23

SP - 2061

EP - 2064

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 7

ER -

Demonstration of a sucrose-derived contrast agent for magnetic resonance imaging of the GI tract

Abstract

Keywords

ASJC Scopus subject areas

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