Demonstration of a sucrose-derived contrast agent for magnetic resonance imaging of the GI tract

Gary V. Martinez; Suryakiran Navath; Kamini Sewda; Venkataramanarao Rao; Parastou Foroutan; Ramesh Alleti; Valerie E. Moberg; Ali M. Ahad; Domenico Coppola; Mark C. Lloyd; Robert J. Gillies; David L. Morse; Eugene A. Mash

doi:10.1016/j.bmcl.2013.02.008

Demonstration of a sucrose-derived contrast agent for magnetic resonance imaging of the GI tract

Gary V. Martinez, Suryakiran Navath, Kamini Sewda, Venkataramanarao Rao, Parastou Foroutan, Ramesh Alleti, Valerie E. Moberg, Ali M. Ahad, Domenico Coppola, Mark C. Lloyd, Robert J. Gillies, David L. Morse, Eugene A. Mash

Chemistry and Biochemistry

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

A scaffold bearing eight terminal alkyne groups was synthesized from sucrose, and copies of an azide-terminated Gd-DOTA complex were attached via copper(I)-catalyzed azide-alkyne cycloaddition. The resulting contrast agent (CA) was administered by gavage to C3H mice. Passage of the CA through the gastrointestinal (GI) tract was followed by T₁-weighted magnetic resonance imaging (MRI) over a period of 47 h, by which time the CA had exited the GI tract. No evidence for leakage of the CA from the GI tract was observed. Thus, a new, orally administered CA for MRI of the GI tract has been developed and successfully demonstrated.

Original language	English (US)
Pages (from-to)	2061-2064
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	23
Issue number	7
DOIs	https://doi.org/10.1016/j.bmcl.2013.02.008
State	Published - Apr 1 2013

Keywords

Contrast agent
DOTA
Gadolinium
Gastrointestinal tract
Magnetic resonance imaging

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/j.bmcl.2013.02.008

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Martinez, G. V., Navath, S., Sewda, K., Rao, V., Foroutan, P., Alleti, R., Moberg, V. E., Ahad, A. M., Coppola, D., Lloyd, M. C., Gillies, R. J., Morse, D. L., & Mash, E. A. (2013). Demonstration of a sucrose-derived contrast agent for magnetic resonance imaging of the GI tract. Bioorganic and Medicinal Chemistry Letters, 23(7), 2061-2064. https://doi.org/10.1016/j.bmcl.2013.02.008

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title = "Demonstration of a sucrose-derived contrast agent for magnetic resonance imaging of the GI tract",

abstract = "A scaffold bearing eight terminal alkyne groups was synthesized from sucrose, and copies of an azide-terminated Gd-DOTA complex were attached via copper(I)-catalyzed azide-alkyne cycloaddition. The resulting contrast agent (CA) was administered by gavage to C3H mice. Passage of the CA through the gastrointestinal (GI) tract was followed by T1-weighted magnetic resonance imaging (MRI) over a period of 47 h, by which time the CA had exited the GI tract. No evidence for leakage of the CA from the GI tract was observed. Thus, a new, orally administered CA for MRI of the GI tract has been developed and successfully demonstrated.",

keywords = "Contrast agent, DOTA, Gadolinium, Gastrointestinal tract, Magnetic resonance imaging",

author = "Martinez, \{Gary V.\} and Suryakiran Navath and Kamini Sewda and Venkataramanarao Rao and Parastou Foroutan and Ramesh Alleti and Moberg, \{Valerie E.\} and Ahad, \{Ali M.\} and Domenico Coppola and Lloyd, \{Mark C.\} and Gillies, \{Robert J.\} and Morse, \{David L.\} and Mash, \{Eugene A.\}",

note = "Funding Information: This work was supported by Grants R33 CA 95944 , RO1 CA 97360 , RO1 CA 123547 , and P30 CA 23074 from the National Cancer Institute . ",

year = "2013",

month = apr,

day = "1",

doi = "10.1016/j.bmcl.2013.02.008",

language = "English (US)",

volume = "23",

pages = "2061--2064",

journal = "Bioorganic and Medicinal Chemistry Letters",

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T1 - Demonstration of a sucrose-derived contrast agent for magnetic resonance imaging of the GI tract

AU - Martinez, Gary V.

AU - Navath, Suryakiran

AU - Sewda, Kamini

AU - Rao, Venkataramanarao

AU - Foroutan, Parastou

AU - Alleti, Ramesh

AU - Moberg, Valerie E.

AU - Ahad, Ali M.

AU - Coppola, Domenico

AU - Lloyd, Mark C.

AU - Gillies, Robert J.

AU - Morse, David L.

AU - Mash, Eugene A.

N1 - Funding Information: This work was supported by Grants R33 CA 95944 , RO1 CA 97360 , RO1 CA 123547 , and P30 CA 23074 from the National Cancer Institute .

PY - 2013/4/1

Y1 - 2013/4/1

N2 - A scaffold bearing eight terminal alkyne groups was synthesized from sucrose, and copies of an azide-terminated Gd-DOTA complex were attached via copper(I)-catalyzed azide-alkyne cycloaddition. The resulting contrast agent (CA) was administered by gavage to C3H mice. Passage of the CA through the gastrointestinal (GI) tract was followed by T1-weighted magnetic resonance imaging (MRI) over a period of 47 h, by which time the CA had exited the GI tract. No evidence for leakage of the CA from the GI tract was observed. Thus, a new, orally administered CA for MRI of the GI tract has been developed and successfully demonstrated.

AB - A scaffold bearing eight terminal alkyne groups was synthesized from sucrose, and copies of an azide-terminated Gd-DOTA complex were attached via copper(I)-catalyzed azide-alkyne cycloaddition. The resulting contrast agent (CA) was administered by gavage to C3H mice. Passage of the CA through the gastrointestinal (GI) tract was followed by T1-weighted magnetic resonance imaging (MRI) over a period of 47 h, by which time the CA had exited the GI tract. No evidence for leakage of the CA from the GI tract was observed. Thus, a new, orally administered CA for MRI of the GI tract has been developed and successfully demonstrated.

KW - Contrast agent

KW - DOTA

KW - Gadolinium

KW - Gastrointestinal tract

KW - Magnetic resonance imaging

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AN - SCOPUS:84875214927

SN - 0960-894X

VL - 23

SP - 2061

EP - 2064

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 7

ER -

Demonstration of a sucrose-derived contrast agent for magnetic resonance imaging of the GI tract

Abstract

Keywords

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