Democratization of Nanoscale Imaging and Sensing Tools Using Photonics

Euan McLeod, Qingshan Wei, Aydogan Ozcan

Research output: Contribution to journalReview articlepeer-review

41 Scopus citations


Providing means for researchers and citizen scientists in the developing world to perform advanced measurements with nanoscale precision can help to accelerate the rate of discovery and invention as well as improve higher education and the training of the next generation of scientists and engineers worldwide. Here, we review some of the recent progress toward making optical nanoscale measurement tools more cost-effective, field-portable, and accessible to a significantly larger group of researchers and educators. We divide our review into two main sections: label-based nanoscale imaging and sensing tools, which primarily involve fluorescent approaches, and label-free nanoscale measurement tools, which include light scattering sensors, interferometric methods, photonic crystal sensors, and plasmonic sensors. For each of these areas, we have primarily focused on approaches that have either demonstrated operation outside of a traditional laboratory setting, including for example integration with mobile phones, or exhibited the potential for such operation in the near future. (Figure Presented).

Original languageEnglish (US)
Pages (from-to)6434-6445
Number of pages12
JournalAnalytical Chemistry
Issue number13
StatePublished - Jul 7 2015
Externally publishedYes

ASJC Scopus subject areas

  • Analytical Chemistry


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