Delivery of Short Hairpin RNA Sequences by Using a Replication-Competent Avian Retroviral Vector

Jennifer L. Bromberg-White, Craig P. Webb, Veronique S. Patacsil, Cindy K. Miranti, Bart O. Williams, Sheri L. Holmen

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

While recent studies have demonstrated that retroviral vectors can be used to stably express short hairpin RNA (shRNA) to inhibit gene expression, these studies have utilized replication-defective retroviruses. We describe the creation of a replication-competent, Gateway-compatible retroviral vector capable of expressing shRNA that inhibits the expression of specific genes.

Original languageEnglish (US)
Pages (from-to)4914-4916
Number of pages3
JournalJournal of virology
Volume78
Issue number9
DOIs
StatePublished - May 2004
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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