TY - JOUR
T1 - Degradation kinetics of 4-dedimethylamino sancycline, a new anti-tumor agent, in aqueous solutions
AU - Pinsuwan, Sirirat
AU - Alvarez-Núñez, Fernando A.
AU - Tabibi, Esmail S.
AU - Yalkowsky, Samuel H.
N1 - Funding Information:
This work was partially performed under contract No. N01-CM-27757 from the National Cancer Institute. Also, we thank the CONACYT and the UNAM of México. The work of Mi Jin Kim, Purvi Shah and Chuck Leung is appreciated.
PY - 1999/4/20
Y1 - 1999/4/20
N2 - The kinetics of degradation of the new anti-tumor drug, 4-dedimethylamino sancycline (col-3) in aqueous solution at 25(o)C were investigated by high-pressure liquid chromatography (HPLC) over the pH-range of 2-10. The influences of pH, buffer concentration, light, temperature, and some additives on the degradation rate were studied. The degradation of col-3 was found to follow first order kinetics. A rate expression covering the degradation of the various ionic forms of the drug was derived and shown to account for the shape of the experimental pH-rate profile. Under basic conditions, the degradation of col-3 involves oxidation, which is catalyzed by metal ions and inhibited by EDTA and Sodium bisulfite. Copyright (C) 1999 Elsevier Science B.V.
AB - The kinetics of degradation of the new anti-tumor drug, 4-dedimethylamino sancycline (col-3) in aqueous solution at 25(o)C were investigated by high-pressure liquid chromatography (HPLC) over the pH-range of 2-10. The influences of pH, buffer concentration, light, temperature, and some additives on the degradation rate were studied. The degradation of col-3 was found to follow first order kinetics. A rate expression covering the degradation of the various ionic forms of the drug was derived and shown to account for the shape of the experimental pH-rate profile. Under basic conditions, the degradation of col-3 involves oxidation, which is catalyzed by metal ions and inhibited by EDTA and Sodium bisulfite. Copyright (C) 1999 Elsevier Science B.V.
KW - 4-Dedimethylamino sancycline
KW - Anti-tumor agent
KW - Aqueous solutions
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U2 - 10.1016/S0378-5173(98)00417-7
DO - 10.1016/S0378-5173(98)00417-7
M3 - Article
C2 - 10370200
AN - SCOPUS:0344004863
SN - 0378-5173
VL - 181
SP - 31
EP - 40
JO - International Journal of Pharmaceutics
JF - International Journal of Pharmaceutics
IS - 1
ER -