Defining the specific physiological requirements for c-Myc in T cell development

Nataki C. Douglas, Harris Jacobs, Alfred L.M. Bothwell, Adrian C. Hayday

Research output: Contribution to journalArticlepeer-review

87 Scopus citations

Abstract

c-Myc is associated with cell growth and cycling in many tissues and its deregulated expression is causally implicated in cancer, particularly lymphomagenesis. However, the contribution of c-Myc to lymphocyte development is unresolved. We show here that the formation of normal lymphocytes by c-Myc-/- cells is selectively defective. c-Myc-/- cells are inefficient, in an age-dependent manner, at populating the thymus, and subsequent thymocyte maturation is ineffective: they fail to grow and proliferate normally at the late double-negative (DN) CD4-CD8- stage. Because N-Myc expression in thymocytes usually declines at the late DN stage, these results confirm that the nonredundant contributions of Myc family members to development are related to their distinct patterns of developmental gene expression.

Original languageEnglish (US)
Pages (from-to)307-315
Number of pages9
JournalNature immunology
Volume2
Issue number4
DOIs
StatePublished - Apr 2001
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Fingerprint

Dive into the research topics of 'Defining the specific physiological requirements for c-Myc in T cell development'. Together they form a unique fingerprint.

Cite this