TY - JOUR
T1 - Deep homology of arthropod central complex and vertebrate basal ganglia
AU - Strausfeld, Nicholas J.
AU - Hirth, Frank
PY - 2013/4/12
Y1 - 2013/4/12
N2 - The arthropod central complex and vertebrate basal ganglia derive from embryonic basal forebrain lineages that are specified by an evolutionarily conserved genetic program leading to interconnected neuropils and nuclei that populate the midline of the forebrain-midbrain boundary region. In the substructures of both the central complex and basal ganglia, network connectivity and neuronal activity mediate control mechanisms in which inhibitory (GABAergic) and modulatory (dopaminergic) circuits facilitate the regulation and release of adaptive behaviors. Both basal ganglia and central complex dysfunction result in behavioral defects including motor abnormalities, impaired memory formation, attention deficits, affective disorders, and sleep disturbances. The observed multitude of similarities suggests deep homology of arthropod central complex and vertebrate basal ganglia circuitries underlying the selection and maintenance of behavioral actions.
AB - The arthropod central complex and vertebrate basal ganglia derive from embryonic basal forebrain lineages that are specified by an evolutionarily conserved genetic program leading to interconnected neuropils and nuclei that populate the midline of the forebrain-midbrain boundary region. In the substructures of both the central complex and basal ganglia, network connectivity and neuronal activity mediate control mechanisms in which inhibitory (GABAergic) and modulatory (dopaminergic) circuits facilitate the regulation and release of adaptive behaviors. Both basal ganglia and central complex dysfunction result in behavioral defects including motor abnormalities, impaired memory formation, attention deficits, affective disorders, and sleep disturbances. The observed multitude of similarities suggests deep homology of arthropod central complex and vertebrate basal ganglia circuitries underlying the selection and maintenance of behavioral actions.
UR - http://www.scopus.com/inward/record.url?scp=84876307446&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84876307446&partnerID=8YFLogxK
U2 - 10.1126/science.1231828
DO - 10.1126/science.1231828
M3 - Review article
C2 - 23580521
AN - SCOPUS:84876307446
SN - 0036-8075
VL - 340
SP - 157
EP - 161
JO - Science
JF - Science
IS - 6129
ER -