Deep Brain Stimulation Surgery for Essential Tremor in a Patient with Type A Hemophilia

Ryan Palsma, Nicholas Gravbrot, Robert Bina, Manas Agastya, Willard S. Kasoff

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Background: Hemophilia is generally considered a contraindication to deep brain stimulation (DBS) and other elective intracranial surgery because of the elevated risk of perioperative hemorrhage. Two prior case reports have suggested, however, that DBS may be safe in patients with hemophilia who undergo appropriate factor replacement. Here, we describe a third case of DBS surgery for medically refractory essential tremor (ET) in a patient with hemophilia A. Case Description: A 68-year-old right-handed man with mild hemophilia A presented for a 10-year history of bilateral (right greater than left), medically refractory ET. The patient was considered an appropriate candidate for DBS by a multidisciplinary movement disorders conference, and hematology consultation was obtained. Baseline preoperative laboratory results showed a quantitative factor VIII (FVIII) level of 38%. Perioperative management consisted of daily intravenous bolus doses of recombinant FVIII from the morning of surgery to postoperative day 10. The patient underwent uncomplicated unilateral DBS placement in the left ventralis intermedius thalamus. Intra- and postoperative imaging showed no hemorrhage. His postoperative course was uncomplicated except for a single self-limited episode of hematuria requiring no intervention. Conclusions: DBS placement for ET may be safe in patients with coexisting hemophilia A if appropriate FVIII replacement is given, which may be delivered as bolus infusions rather than continuous infusion.

Original languageEnglish (US)
Pages (from-to)158-162
Number of pages5
JournalWorld neurosurgery
StatePublished - Jul 2020


  • Deep brain stimulation
  • Essential tremor
  • Hemophilia

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology


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