Deep Brain Stimulation for the Treatment of Epilepsy: Circuits, Targets, and Trials

Nealen G. Laxpati, Willard S. Kasoff, Robert E. Gross

Research output: Contribution to journalReview articlepeer-review

136 Scopus citations


Deep brain stimulation (DBS) has proven remarkably safe and effective in the treatment of movement disorders. As a result, it is being increasingly applied to a range of neurologic and psychiatric disorders, including medically refractory epilepsy. This review will examine the use of DBS in epilepsy, including known targets, mechanisms of neuromodulation and seizure control, published clinical evidence, and novel technologies. Cortical and deep neuromodulation for epilepsy has a long experimental history, but only recently have better understanding of epileptogenic networks, precise stereotactic techniques, and rigorous trial design combined to improve the quality of available evidence and make DBS a viable treatment option. Nonetheless, underlying mechanisms, anatomical targets, and stimulation parameters remain areas of active investigation.

Original languageEnglish (US)
Pages (from-to)508-526
Number of pages19
Issue number3
StatePublished - Jul 2014


  • Epilepsy
  • anterior nucleus
  • centromedian nucleus
  • deep brain stimulation
  • neuromodulation

ASJC Scopus subject areas

  • Pharmacology
  • Clinical Neurology
  • Pharmacology (medical)


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