TY - JOUR
T1 - Dedicated cone-beam breast CT using laterally-shifted detector geometry
T2 - Quantitative analysis of feasibility for clinical translation
AU - Vedantham, Srinivasan
AU - Tseng, Hsin Wu
AU - Konate, Souleymane
AU - Shi, Linxi
AU - Karellas, Andrew
N1 - Publisher Copyright:
© 2020 - IOS Press and the authors. All rights reserved.
PY - 2020
Y1 - 2020
N2 - BACKGROUND: High-resolution, low-noise detectors with minimal dead-space at chest-wall could improve posterior coverage and microcalcification visibility in the dedicated cone-beam breast CT (CBBCT). However, the smaller field-of-view necessitates laterally-shifted detector geometry to enable optimizing the air-gap for x-ray scatter rejection. OBJECTIVE: To evaluate laterally-shifted detector geometry for CBBCT with clinical projection datasets that provide for anatomical structures and lesions. METHODS: CBBCT projection datasets (n=17 breasts) acquired with a 40×30cm detector (1024×768-pixels, 0.388-mm pixels) were truncated along the fan-angle to emulate 20.3×30cm, 22.2×30cm and 24.1×30cm detector formats and correspond to 20, 120, 220 pixels overlap in conjugate views, respectively. Feldkamp-Davis-Kress (FDK) algorithm with 3 different weighting schemes were used for reconstruction. Visual analysis for artifacts and quantitative analysis of root-mean-squared-error (RMSE), absolute difference between truncated and 40×30cm reconstructions (Diff), and its power spectrum (PSDiff) were performed. RESULTS: Artifacts were observed for 20.3×30cm, but not for other formats. The 24.1×30cm provided the best quantitative results with RMSE and Diff (both in units of μ, cm-1) of 4.39×10-3±1.98×10-3 and 4.95×10-4±1.34×10-4, respectively. The PSDiff (>0.3 cycles/mm) was in the order of 10-14μ2mm3 and was spatial-frequency independent. CONCLUSIONS: Laterally-shifted detector CBBCT with at least 220 pixels overlap in conjugate views (24.1×30cm detector format) provides quantitatively accurate and artifact-free image reconstruction.
AB - BACKGROUND: High-resolution, low-noise detectors with minimal dead-space at chest-wall could improve posterior coverage and microcalcification visibility in the dedicated cone-beam breast CT (CBBCT). However, the smaller field-of-view necessitates laterally-shifted detector geometry to enable optimizing the air-gap for x-ray scatter rejection. OBJECTIVE: To evaluate laterally-shifted detector geometry for CBBCT with clinical projection datasets that provide for anatomical structures and lesions. METHODS: CBBCT projection datasets (n=17 breasts) acquired with a 40×30cm detector (1024×768-pixels, 0.388-mm pixels) were truncated along the fan-angle to emulate 20.3×30cm, 22.2×30cm and 24.1×30cm detector formats and correspond to 20, 120, 220 pixels overlap in conjugate views, respectively. Feldkamp-Davis-Kress (FDK) algorithm with 3 different weighting schemes were used for reconstruction. Visual analysis for artifacts and quantitative analysis of root-mean-squared-error (RMSE), absolute difference between truncated and 40×30cm reconstructions (Diff), and its power spectrum (PSDiff) were performed. RESULTS: Artifacts were observed for 20.3×30cm, but not for other formats. The 24.1×30cm provided the best quantitative results with RMSE and Diff (both in units of μ, cm-1) of 4.39×10-3±1.98×10-3 and 4.95×10-4±1.34×10-4, respectively. The PSDiff (>0.3 cycles/mm) was in the order of 10-14μ2mm3 and was spatial-frequency independent. CONCLUSIONS: Laterally-shifted detector CBBCT with at least 220 pixels overlap in conjugate views (24.1×30cm detector format) provides quantitatively accurate and artifact-free image reconstruction.
KW - Breast
KW - X-Ray computed tomography (CT)
KW - breast CT
KW - cone-beam CT
KW - mammography
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U2 - 10.3233/XST-200651
DO - 10.3233/XST-200651
M3 - Article
C2 - 32333575
AN - SCOPUS:85086524541
SN - 0895-3996
VL - 28
SP - 405
EP - 426
JO - Journal of X-Ray Science and Technology
JF - Journal of X-Ray Science and Technology
IS - 3
ER -