Abstract
A study was designed to examine the testicular function of male offspring rats produced by diabetic dams. A marked decrease in testosterone response to exogenous administration of gonadotropin-releasing hormone (GnRH) was found in male offspring of female rats made diabetic by administration of streptozotocin during early pregnancy. Control rats responded to GnRH with a marked increase in serum testosterone within 4-h postinjection. Male offspring of diabetic female rats demonstrated an unexpected decrease in serum testosterone in response to GnRH when compared with saline-injected rats. The results suggest that a defect in Leydig cell function may occur in the male offspring of diabetic female rats. However, a decreased release of pituitary LH in response to exogenous GnRH stimulation cannot be excluded as a cause of the lower testosterone values.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 11-16 |
| Number of pages | 6 |
| Journal | Systems Biology in Reproductive Medicine |
| Volume | 21 |
| Issue number | 2 |
| DOIs | |
| State | Published - 1988 |
| Externally published | Yes |
Keywords
- Diabetes
- GnRH
- Rats
- Testosterone
ASJC Scopus subject areas
- Reproductive Medicine
- Urology