Decoupling cell and matrix mechanics in engineered microtissues using magnetically actuated microcantilevers

Ruogang Zhao; Thomas Boudou; Wei Gang Wang; Christopher S. Chen; Daniel H. Reich

doi:10.1002/adma.201203585

Decoupling cell and matrix mechanics in engineered microtissues using magnetically actuated microcantilevers

Ruogang Zhao, Thomas Boudou, Wei Gang Wang, Christopher S. Chen, Daniel H. Reich

Physics

Research output: Contribution to journal › Article › peer-review

82 Scopus citations

Abstract

A novel bio-magnetomechanical microtissue system is described for magnetic actuation of arrays of 3D microtissues using microcantilevers. This system enables both in situ measurements of fundamental mechanical properties of engineered tissue, such as contractility and stiffness, as well as dynamic stimulation of the microtissues. Using this system, cell and extracellular matrix contributions to the tissue mechanical properties are decoupled for the first time under both static and dynamic loading conditions.

Original language	English (US)
Pages (from-to)	1699-1705
Number of pages	7
Journal	Advanced Materials
Volume	25
Issue number	12
DOIs	https://doi.org/10.1002/adma.201203585
State	Published - Mar 25 2013

Keywords

cell contractility
engineered microtissue
fibroblast populated collagen matrix
magnetic actuation
tissue stiffness

ASJC Scopus subject areas

Materials Science(all)
Mechanics of Materials
Mechanical Engineering

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10.1002/adma.201203585

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abstract = "A novel bio-magnetomechanical microtissue system is described for magnetic actuation of arrays of 3D microtissues using microcantilevers. This system enables both in situ measurements of fundamental mechanical properties of engineered tissue, such as contractility and stiffness, as well as dynamic stimulation of the microtissues. Using this system, cell and extracellular matrix contributions to the tissue mechanical properties are decoupled for the first time under both static and dynamic loading conditions.",

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author = "Ruogang Zhao and Thomas Boudou and Wang, {Wei Gang} and Chen, {Christopher S.} and Reich, {Daniel H.}",

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AU - Zhao, Ruogang

AU - Boudou, Thomas

AU - Wang, Wei Gang

AU - Chen, Christopher S.

AU - Reich, Daniel H.

PY - 2013/3/25

Y1 - 2013/3/25

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AB - A novel bio-magnetomechanical microtissue system is described for magnetic actuation of arrays of 3D microtissues using microcantilevers. This system enables both in situ measurements of fundamental mechanical properties of engineered tissue, such as contractility and stiffness, as well as dynamic stimulation of the microtissues. Using this system, cell and extracellular matrix contributions to the tissue mechanical properties are decoupled for the first time under both static and dynamic loading conditions.

KW - cell contractility

KW - engineered microtissue

KW - fibroblast populated collagen matrix

KW - magnetic actuation

KW - tissue stiffness

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Decoupling cell and matrix mechanics in engineered microtissues using magnetically actuated microcantilevers

Abstract

Keywords

ASJC Scopus subject areas

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