Daytime sleepiness is associated with altered resting thalamocortical connectivity

William D.S. Killgore, John R. Vanuk, Sara A. Knight, Sarah M. Markowski, Derek Pisner, Bradley Shane, Andrew Fridman, Anna Alkozei

Research output: Contribution to journalArticlepeer-review

34 Scopus citations


Thalamocortical connectivity is believed to underlie basic alertness, motor, sensory information processing, and attention processes. This connectivity appears to be disrupted by total sleep deprivation, but it is not known whether it is affected by normal variations in general daytime sleepiness in nonsleep deprived persons. Healthy adult participants completed the Epworth Sleepiness Scale and underwent resting-state functional MRI. Functional connectivity between the thalamus and other regions of the cortex was examined and correlated with Epworth Sleepiness Scale scores. Greater sleepiness was associated with inverse (i.e. lower or more negative) connectivity between the bilateral thalamus and cortical regions involved in somatosensory and motor functions, potentially reflecting the disengagement of sensory and motor processing from the stream of consciousness.

Original languageEnglish (US)
Pages (from-to)779-784
Number of pages6
Issue number13
StatePublished - Aug 19 2015


  • functional MRI
  • functional connectivity
  • medial prefrontal cortex
  • motor cortex
  • neuroimaging
  • parietal cortex
  • sensory cortex
  • sleepiness

ASJC Scopus subject areas

  • General Neuroscience


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