DARPA's Big Mechanism program

Paul R. Cohen

    Research output: Contribution to journalArticlepeer-review

    54 Scopus citations


    Reductionist science produces causal models of small fragments of complicated systems. Causal models of entire systems can be hard to construct because what is known of them is distributed across a vast amount of literature. The Big Mechanism program aims to have machines read the literature and assemble the causal fragments found in individual papers into huge causal models, automatically. The current domain of the program is cell signalling associated with Ras-driven cancers.

    Original languageEnglish (US)
    Article number045008
    JournalPhysical Biology
    Issue number4
    StatePublished - Jul 1 2015


    • artificial intelligence
    • biocuration
    • information extraction
    • machine reading
    • modeling
    • signaling pathways
    • systems biology

    ASJC Scopus subject areas

    • Biophysics
    • Structural Biology
    • Molecular Biology
    • Cell Biology


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