CYTOTOXIC T LYMPHOCYTE RECOGNITION OF HYBRID MHC CLASS I MOLECULES

T. Kanda; M. J. Macchi; K. LaPan; M. Darsley; E. Appella; J. A. Frelinger

doi:10.1111/j.1744-313X.1988.tb00433.x

CYTOTOXIC T LYMPHOCYTE RECOGNITION OF HYBRID MHC CLASS I MOLECULES

T. Kanda, M. J. Macchi, K. LaPan, M. Darsley, E. Appella, J. A. Frelinger

Immunobiology

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

We have utilized a group of MHC class I genes produced by in vitro recombination between D^p and D^d to study recognition of MHC class I molecules by cytolytic T cells (CTLs). Both polyclonal allo‐specific and H‐2‐restricted CTLs require that α1 and a² of the target class I molecule be derived from the same haplotype for efficient killing. By using T‐cell lines we showed that within the bulk population there must exist a fraction of T cells which can recognize epitopes in al or α2. Critical residues for T‐cell recognition have been identified using these chimeric genes.

Original language	English (US)
Pages (from-to)	295-305
Number of pages	11
Journal	International Journal of Immunogenetics
Volume	15
Issue number	5-6
DOIs	https://doi.org/10.1111/j.1744-313X.1988.tb00433.x
State	Published - Oct 1988

ASJC Scopus subject areas

Immunology
Molecular Biology
Genetics
Genetics(clinical)

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title = "CYTOTOXIC T LYMPHOCYTE RECOGNITION OF HYBRID MHC CLASS I MOLECULES",

abstract = "We have utilized a group of MHC class I genes produced by in vitro recombination between Dp and Dd to study recognition of MHC class I molecules by cytolytic T cells (CTLs). Both polyclonal allo‐specific and H‐2‐restricted CTLs require that α1 and a2 of the target class I molecule be derived from the same haplotype for efficient killing. By using T‐cell lines we showed that within the bulk population there must exist a fraction of T cells which can recognize epitopes in al or α2. Critical residues for T‐cell recognition have been identified using these chimeric genes.",

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AU - Kanda, T.

AU - Macchi, M. J.

AU - LaPan, K.

AU - Darsley, M.

AU - Appella, E.

AU - Frelinger, J. A.

PY - 1988/10

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AB - We have utilized a group of MHC class I genes produced by in vitro recombination between Dp and Dd to study recognition of MHC class I molecules by cytolytic T cells (CTLs). Both polyclonal allo‐specific and H‐2‐restricted CTLs require that α1 and a2 of the target class I molecule be derived from the same haplotype for efficient killing. By using T‐cell lines we showed that within the bulk population there must exist a fraction of T cells which can recognize epitopes in al or α2. Critical residues for T‐cell recognition have been identified using these chimeric genes.

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CYTOTOXIC T LYMPHOCYTE RECOGNITION OF HYBRID MHC CLASS I MOLECULES

Abstract

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