Cytotoxic cytochalasins and other metabolites from xylariaceae sp. FL0390, a fungal endophyte of Spanish moss

Ya Ming Xu; Bharat P. Bashyal; Mangping X. Liu; Patricia Espinosa-Artiles; Jana M. U'Ren; A. Elizabeth Arnold; A. A.Leslie Gunatilaka

doi:10.1177/1934578x1501001007

Cytotoxic cytochalasins and other metabolites from xylariaceae sp. FL0390, a fungal endophyte of Spanish moss

Ya Ming Xu, Bharat P. Bashyal, Mangping X. Liu, Patricia Espinosa-Artiles, Jana M. U'Ren, A. Elizabeth Arnold, A. A.Leslie Gunatilaka

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Two new metabolites, 6-oxo-12-norcytochalasin D (1) and 4,5-di-isobutyl-2(1H)-pyrimidinone (2), together with seven known metabolites, cytochalasins D (3), Q (4), and N (5), 12-hydroxyzygosporin G (6), heptelidic acid chlorohydrin (7), (+)-heptelidic acid (8), and trichoderonic acid A (9), were isolated from Xylariaceae sp. FL0390, a fungal endophyte inhabiting Spanish moss, Tillandsia usneoides. Metabolite 1 is the first example of a 12-norcytochalasin. All metabolites, except 2 and 9, showed cytotoxic activity in a panel of five human tumor cell lines with IC₅₀s of 0.2-5.0 μM.

Original language	English (US)
Pages (from-to)	1655-1658
Number of pages	4
Journal	Natural Product Communications
Volume	10
Issue number	10
DOIs	https://doi.org/10.1177/1934578x1501001007
State	Published - Oct 2015

Keywords

4,5-Di-isobuty-2(1H)-pyrimidinone
6-Oxo-12-norcytochalasin D
Cytochalasins
Cytotoxic activity
Endophytic fungus
Tillandsia usneoides
Xylariaceae

ASJC Scopus subject areas

Drug Discovery
Complementary and alternative medicine
Plant Science
Pharmacology

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10.1177/1934578x1501001007

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@article{d1d6cf93449b4af7b76bdfec8fd22e04,

title = "Cytotoxic cytochalasins and other metabolites from xylariaceae sp. FL0390, a fungal endophyte of Spanish moss",

abstract = "Two new metabolites, 6-oxo-12-norcytochalasin D (1) and 4,5-di-isobutyl-2(1H)-pyrimidinone (2), together with seven known metabolites, cytochalasins D (3), Q (4), and N (5), 12-hydroxyzygosporin G (6), heptelidic acid chlorohydrin (7), (+)-heptelidic acid (8), and trichoderonic acid A (9), were isolated from Xylariaceae sp. FL0390, a fungal endophyte inhabiting Spanish moss, Tillandsia usneoides. Metabolite 1 is the first example of a 12-norcytochalasin. All metabolites, except 2 and 9, showed cytotoxic activity in a panel of five human tumor cell lines with IC50s of 0.2-5.0 μM.",

keywords = "4,5-Di-isobuty-2(1H)-pyrimidinone, 6-Oxo-12-norcytochalasin D, Cytochalasins, Cytotoxic activity, Endophytic fungus, Tillandsia usneoides, Xylariaceae",

author = "Xu, {Ya Ming} and Bashyal, {Bharat P.} and Liu, {Mangping X.} and Patricia Espinosa-Artiles and U'Ren, {Jana M.} and Arnold, {A. Elizabeth} and Gunatilaka, {A. A.Leslie}",

year = "2015",

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doi = "10.1177/1934578x1501001007",

language = "English (US)",

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AU - Xu, Ya Ming

AU - Bashyal, Bharat P.

AU - Liu, Mangping X.

AU - Espinosa-Artiles, Patricia

AU - U'Ren, Jana M.

AU - Arnold, A. Elizabeth

AU - Gunatilaka, A. A.Leslie

PY - 2015/10

Y1 - 2015/10

N2 - Two new metabolites, 6-oxo-12-norcytochalasin D (1) and 4,5-di-isobutyl-2(1H)-pyrimidinone (2), together with seven known metabolites, cytochalasins D (3), Q (4), and N (5), 12-hydroxyzygosporin G (6), heptelidic acid chlorohydrin (7), (+)-heptelidic acid (8), and trichoderonic acid A (9), were isolated from Xylariaceae sp. FL0390, a fungal endophyte inhabiting Spanish moss, Tillandsia usneoides. Metabolite 1 is the first example of a 12-norcytochalasin. All metabolites, except 2 and 9, showed cytotoxic activity in a panel of five human tumor cell lines with IC50s of 0.2-5.0 μM.

AB - Two new metabolites, 6-oxo-12-norcytochalasin D (1) and 4,5-di-isobutyl-2(1H)-pyrimidinone (2), together with seven known metabolites, cytochalasins D (3), Q (4), and N (5), 12-hydroxyzygosporin G (6), heptelidic acid chlorohydrin (7), (+)-heptelidic acid (8), and trichoderonic acid A (9), were isolated from Xylariaceae sp. FL0390, a fungal endophyte inhabiting Spanish moss, Tillandsia usneoides. Metabolite 1 is the first example of a 12-norcytochalasin. All metabolites, except 2 and 9, showed cytotoxic activity in a panel of five human tumor cell lines with IC50s of 0.2-5.0 μM.

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KW - 6-Oxo-12-norcytochalasin D

KW - Cytochalasins

KW - Cytotoxic activity

KW - Endophytic fungus

KW - Tillandsia usneoides

KW - Xylariaceae

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Cytotoxic cytochalasins and other metabolites from xylariaceae sp. FL0390, a fungal endophyte of Spanish moss

Abstract

Keywords

ASJC Scopus subject areas

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