Cytotoxic and tumor inhibitory agent from Polygala macradenia gray (Polygalaceae): 4′‐demethyldeoxypodophyllotoxin

Joseph J. Hoffmann; Richard M. Wiedhopf; Jack R. Cole

doi:10.1002/jps.2600660433

Cytotoxic and tumor inhibitory agent from Polygala macradenia gray (Polygalaceae): 4′‐demethyldeoxypodophyllotoxin

Joseph J. Hoffmann
, Richard M. Wiedhopf
, Jack R. Cole

Pharmacy Practice and Science

Research output: Contribution to journal › Comment/debate › peer-review

16 Scopus citations

Abstract

The chloroform fraction of Polygala macradenia exhibited activity against the P‐388 lymphocytic leukemia and human epidermoid carcinoma of the nasopharynx test systems. The constituent responsible for this activity was a lignan, 4′‐demethyldeoxypodophyllotoxin (C₂₁H₂₀C₇). The identity was proven by elemental analysis; PMR, IR, mass spectrometric, and melting‐point determinations; and preparation of a derivative.

Original language	English (US)
Pages (from-to)	586-587
Number of pages	2
Journal	Journal of pharmaceutical sciences
Volume	66
Issue number	4
DOIs	https://doi.org/10.1002/jps.2600660433
State	Published - Apr 1977

Keywords

4′‐Demethyldeoxypodophyllotoxin—isolated from chloroform fraction of extract of aerial parts of Polygala macradenia, evaluated for cytotoxic and tumor inhibitory activity
Cytotoxic activity—lignan isolated from chloroform fraction of extract of aerial parts of Polygala macradenia evaluated
Polygala macradenia—chloroform fraction of extract of aerial parts, lignan isolated, evaluated for cytotoxic and tumor inhibitory activity
Tumor inhibitory activity—lignan isolated from chloroform fraction of extract of aerial parts of Polygala macradenia evaluated

ASJC Scopus subject areas

Pharmaceutical Science

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10.1002/jps.2600660433

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title = "Cytotoxic and tumor inhibitory agent from Polygala macradenia gray (Polygalaceae): 4′‐demethyldeoxypodophyllotoxin",

abstract = "The chloroform fraction of Polygala macradenia exhibited activity against the P‐388 lymphocytic leukemia and human epidermoid carcinoma of the nasopharynx test systems. The constituent responsible for this activity was a lignan, 4′‐demethyldeoxypodophyllotoxin (C21H20C7). The identity was proven by elemental analysis; PMR, IR, mass spectrometric, and melting‐point determinations; and preparation of a derivative.",

keywords = "4′‐Demethyldeoxypodophyllotoxin—isolated from chloroform fraction of extract of aerial parts of Polygala macradenia, evaluated for cytotoxic and tumor inhibitory activity, Cytotoxic activity—lignan isolated from chloroform fraction of extract of aerial parts of Polygala macradenia evaluated, Polygala macradenia—chloroform fraction of extract of aerial parts, lignan isolated, evaluated for cytotoxic and tumor inhibitory activity, Tumor inhibitory activity—lignan isolated from chloroform fraction of extract of aerial parts of Polygala macradenia evaluated",

author = "Hoffmann, \{Joseph J.\} and Wiedhopf, \{Richard M.\} and Cole, \{Jack R.\}",

note = "Funding Information: University School of Medicine, Stanford, CA 94305. Accepted for publication June 22, 1976. Supported by NIH Grant HL-5866 and Program Project Grant 1- PO1 - 15833. The assistance of Mr. Joseph B. Keenaghan in supplying a number of compounds for investigation as internal standards is appreciated. The authors also thank Mrs. Dorothy McCain for her editorial assistance. To whom inquiries should be directed.",

year = "1977",

month = apr,

doi = "10.1002/jps.2600660433",

language = "English (US)",

volume = "66",

pages = "586--587",

journal = "Journal of pharmaceutical sciences",

issn = "0022-3549",

publisher = "Elsevier B.V.",

number = "4",

}

TY - JOUR

T1 - Cytotoxic and tumor inhibitory agent from Polygala macradenia gray (Polygalaceae)

T2 - 4′‐demethyldeoxypodophyllotoxin

AU - Hoffmann, Joseph J.

AU - Wiedhopf, Richard M.

AU - Cole, Jack R.

N1 - Funding Information: University School of Medicine, Stanford, CA 94305. Accepted for publication June 22, 1976. Supported by NIH Grant HL-5866 and Program Project Grant 1- PO1 - 15833. The assistance of Mr. Joseph B. Keenaghan in supplying a number of compounds for investigation as internal standards is appreciated. The authors also thank Mrs. Dorothy McCain for her editorial assistance. To whom inquiries should be directed.

PY - 1977/4

Y1 - 1977/4

N2 - The chloroform fraction of Polygala macradenia exhibited activity against the P‐388 lymphocytic leukemia and human epidermoid carcinoma of the nasopharynx test systems. The constituent responsible for this activity was a lignan, 4′‐demethyldeoxypodophyllotoxin (C21H20C7). The identity was proven by elemental analysis; PMR, IR, mass spectrometric, and melting‐point determinations; and preparation of a derivative.

AB - The chloroform fraction of Polygala macradenia exhibited activity against the P‐388 lymphocytic leukemia and human epidermoid carcinoma of the nasopharynx test systems. The constituent responsible for this activity was a lignan, 4′‐demethyldeoxypodophyllotoxin (C21H20C7). The identity was proven by elemental analysis; PMR, IR, mass spectrometric, and melting‐point determinations; and preparation of a derivative.

KW - 4′‐Demethyldeoxypodophyllotoxin—isolated from chloroform fraction of extract of aerial parts of Polygala macradenia, evaluated for cytotoxic and tumor inhibitory activity

KW - Cytotoxic activity—lignan isolated from chloroform fraction of extract of aerial parts of Polygala macradenia evaluated

KW - Polygala macradenia—chloroform fraction of extract of aerial parts, lignan isolated, evaluated for cytotoxic and tumor inhibitory activity

KW - Tumor inhibitory activity—lignan isolated from chloroform fraction of extract of aerial parts of Polygala macradenia evaluated

UR - https://www.scopus.com/pages/publications/0017480655

UR - https://www.scopus.com/pages/publications/0017480655#tab=citedBy

U2 - 10.1002/jps.2600660433

DO - 10.1002/jps.2600660433

M3 - Comment/debate

C2 - 853371

AN - SCOPUS:0017480655

SN - 0022-3549

VL - 66

SP - 586

EP - 587

JO - Journal of pharmaceutical sciences

JF - Journal of pharmaceutical sciences

IS - 4

ER -

Cytotoxic and tumor inhibitory agent from Polygala macradenia gray (Polygalaceae): 4′‐demethyldeoxypodophyllotoxin

Abstract

Keywords

ASJC Scopus subject areas

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