TY - JOUR
T1 - Cytotoxic and tumor inhibitory agent from Polygala macradenia gray (Polygalaceae)
T2 - 4′‐demethyldeoxypodophyllotoxin
AU - Hoffmann, Joseph J.
AU - Wiedhopf, Richard M.
AU - Cole, Jack R.
N1 - Funding Information:
University School of Medicine, Stanford, CA 94305. Accepted for publication June 22, 1976. Supported by NIH Grant HL-5866 and Program Project Grant 1- PO1 - 15833. The assistance of Mr. Joseph B. Keenaghan in supplying a number of compounds for investigation as internal standards is appreciated. The authors also thank Mrs. Dorothy McCain for her editorial assistance. To whom inquiries should be directed.
PY - 1977/4
Y1 - 1977/4
N2 - The chloroform fraction of Polygala macradenia exhibited activity against the P‐388 lymphocytic leukemia and human epidermoid carcinoma of the nasopharynx test systems. The constituent responsible for this activity was a lignan, 4′‐demethyldeoxypodophyllotoxin (C21H20C7). The identity was proven by elemental analysis; PMR, IR, mass spectrometric, and melting‐point determinations; and preparation of a derivative.
AB - The chloroform fraction of Polygala macradenia exhibited activity against the P‐388 lymphocytic leukemia and human epidermoid carcinoma of the nasopharynx test systems. The constituent responsible for this activity was a lignan, 4′‐demethyldeoxypodophyllotoxin (C21H20C7). The identity was proven by elemental analysis; PMR, IR, mass spectrometric, and melting‐point determinations; and preparation of a derivative.
KW - 4′‐Demethyldeoxypodophyllotoxin—isolated from chloroform fraction of extract of aerial parts of Polygala macradenia, evaluated for cytotoxic and tumor inhibitory activity
KW - Cytotoxic activity—lignan isolated from chloroform fraction of extract of aerial parts of Polygala macradenia evaluated
KW - Polygala macradenia—chloroform fraction of extract of aerial parts, lignan isolated, evaluated for cytotoxic and tumor inhibitory activity
KW - Tumor inhibitory activity—lignan isolated from chloroform fraction of extract of aerial parts of Polygala macradenia evaluated
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U2 - 10.1002/jps.2600660433
DO - 10.1002/jps.2600660433
M3 - Comment/debate
C2 - 853371
AN - SCOPUS:0017480655
SN - 0022-3549
VL - 66
SP - 586
EP - 587
JO - Journal of pharmaceutical sciences
JF - Journal of pharmaceutical sciences
IS - 4
ER -