Cytotoxic and antigen presenting functions of T helper-1-activated dendritic cells

Nicolas Larmonier; Bernard Bonnotte; Emmanuel Katsanis

doi:10.4161/onci.19370

Cytotoxic and antigen presenting functions of T helper-1-activated dendritic cells

Nicolas Larmonier, Bernard Bonnotte, Emmanuel Katsanis

Research output: Contribution to journal › Comment/debate › peer-review

5 Scopus citations

Abstract

Although primarily defined by their cardinal antigen-presenting function, dendritic cells (DCs) are also equipped with cytotoxic properties. We have recently reported that DCs activated by IFNc-secreting Th-1 lymphocytes can kill cancer cells and subsequently present the acquired tumor-derived antigens to T lymphocytes both in vitro and in vivo.

Original language	English (US)
Pages (from-to)	566-568
Number of pages	3
Journal	OncoImmunology
Volume	1
Issue number	4
DOIs	https://doi.org/10.4161/onci.19370
State	Published - 2012

Keywords

Antigen presentation
Cytotoxic dendritic cells
Th-1 lymphocytes
Tumor
iNOS

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Oncology

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10.4161/onci.19370

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title = "Cytotoxic and antigen presenting functions of T helper-1-activated dendritic cells",

abstract = "Although primarily defined by their cardinal antigen-presenting function, dendritic cells (DCs) are also equipped with cytotoxic properties. We have recently reported that DCs activated by IFNc-secreting Th-1 lymphocytes can kill cancer cells and subsequently present the acquired tumor-derived antigens to T lymphocytes both in vitro and in vivo.",

keywords = "Antigen presentation, Cytotoxic dendritic cells, Th-1 lymphocytes, Tumor, iNOS",

author = "Nicolas Larmonier and Bernard Bonnotte and Emmanuel Katsanis",

year = "2012",

doi = "10.4161/onci.19370",

language = "English (US)",

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AU - Larmonier, Nicolas

AU - Bonnotte, Bernard

AU - Katsanis, Emmanuel

PY - 2012

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N2 - Although primarily defined by their cardinal antigen-presenting function, dendritic cells (DCs) are also equipped with cytotoxic properties. We have recently reported that DCs activated by IFNc-secreting Th-1 lymphocytes can kill cancer cells and subsequently present the acquired tumor-derived antigens to T lymphocytes both in vitro and in vivo.

AB - Although primarily defined by their cardinal antigen-presenting function, dendritic cells (DCs) are also equipped with cytotoxic properties. We have recently reported that DCs activated by IFNc-secreting Th-1 lymphocytes can kill cancer cells and subsequently present the acquired tumor-derived antigens to T lymphocytes both in vitro and in vivo.

KW - Antigen presentation

KW - Cytotoxic dendritic cells

KW - Th-1 lymphocytes

KW - Tumor

KW - iNOS

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U2 - 10.4161/onci.19370

DO - 10.4161/onci.19370

M3 - Comment/debate

AN - SCOPUS:84875076511

SN - 2162-4011

VL - 1

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EP - 568

JO - OncoImmunology

JF - OncoImmunology

IS - 4

ER -

Cytotoxic and antigen presenting functions of T helper-1-activated dendritic cells

Abstract

Keywords

ASJC Scopus subject areas

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