Cytotoxic agents from Michelia champaca and Talauma ovata: Parthenolide and costunolide

Joseph J. Hoffmann, Sterling J. Torrance, Richard M. Wiedhopf, Jack R. Cole

Research output: Contribution to journalArticlepeer-review

34 Scopus citations


The ethanol extract of Michelia champaca and the petroleum ether extract of Talauma ovata showed activity toward the human epidermoid carcinoma of the nasopharynx test system. The active constituents were sesquiterpene lactones, identified as parthenolide (C15H20O3) and costunolide (C15H20O2). Their identities were proven by elemental analyses, PMR, IR, and mass spectral data, melting‐point and mixed melting‐point determinations, and comparisons with authentic samples and spectra.

Original languageEnglish (US)
Pages (from-to)883-884
Number of pages2
JournalJournal of pharmaceutical sciences
Issue number6
StatePublished - Jun 1977


  • Costunolide—isolated from ethanol extract of bark of Michelia champaca and petroleum ether extract of roots of Talauma ovata, cytotoxic activity evaluated
  • Cytotoxic activity—plant constituents parthenolide and costunolide evaluated
  • Michelia champaca—parthenolide and costunolide isolated from ethanol extract of bark, cytotoxic activity evaluated
  • Parthenolide—isolated from ethanol extract of bark of Michelia champaca, cytotoxic activity evaluated
  • Talauma ovata—costunolide isolated from petroleum ether extract of roots, cytotoxic activity evaluated

ASJC Scopus subject areas

  • Pharmaceutical Science


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