Cytotoxic agents from Michelia champaca and Talauma ovata: Parthenolide and costunolide

Joseph J. Hoffmann; Sterling J. Torrance; Richard M. Wiedhopf; Jack R. Cole

doi:10.1002/jps.2600660642

Cytotoxic agents from Michelia champaca and Talauma ovata: Parthenolide and costunolide

Joseph J. Hoffmann, Sterling J. Torrance, Richard M. Wiedhopf, Jack R. Cole

Pharmacy Practice and Science

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

The ethanol extract of Michelia champaca and the petroleum ether extract of Talauma ovata showed activity toward the human epidermoid carcinoma of the nasopharynx test system. The active constituents were sesquiterpene lactones, identified as parthenolide (C₁₅H₂₀O₃) and costunolide (C₁₅H₂₀O₂). Their identities were proven by elemental analyses, PMR, IR, and mass spectral data, melting‐point and mixed melting‐point determinations, and comparisons with authentic samples and spectra.

Original language	English (US)
Pages (from-to)	883-884
Number of pages	2
Journal	Journal of pharmaceutical sciences
Volume	66
Issue number	6
DOIs	https://doi.org/10.1002/jps.2600660642
State	Published - Jun 1977

Keywords

Costunolide—isolated from ethanol extract of bark of Michelia champaca and petroleum ether extract of roots of Talauma ovata, cytotoxic activity evaluated
Cytotoxic activity—plant constituents parthenolide and costunolide evaluated
Michelia champaca—parthenolide and costunolide isolated from ethanol extract of bark, cytotoxic activity evaluated
Parthenolide—isolated from ethanol extract of bark of Michelia champaca, cytotoxic activity evaluated
Talauma ovata—costunolide isolated from petroleum ether extract of roots, cytotoxic activity evaluated

ASJC Scopus subject areas

Pharmaceutical Science

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10.1002/jps.2600660642

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title = "Cytotoxic agents from Michelia champaca and Talauma ovata: Parthenolide and costunolide",

abstract = "The ethanol extract of Michelia champaca and the petroleum ether extract of Talauma ovata showed activity toward the human epidermoid carcinoma of the nasopharynx test system. The active constituents were sesquiterpene lactones, identified as parthenolide (C15H20O3) and costunolide (C15H20O2). Their identities were proven by elemental analyses, PMR, IR, and mass spectral data, melting‐point and mixed melting‐point determinations, and comparisons with authentic samples and spectra.",

keywords = "Costunolide—isolated from ethanol extract of bark of Michelia champaca and petroleum ether extract of roots of Talauma ovata, cytotoxic activity evaluated, Cytotoxic activity—plant constituents parthenolide and costunolide evaluated, Michelia champaca—parthenolide and costunolide isolated from ethanol extract of bark, cytotoxic activity evaluated, Parthenolide—isolated from ethanol extract of bark of Michelia champaca, cytotoxic activity evaluated, Talauma ovata—costunolide isolated from petroleum ether extract of roots, cytotoxic activity evaluated",

author = "Hoffmann, {Joseph J.} and Torrance, {Sterling J.} and Wiedhopf, {Richard M.} and Cole, {Jack R.}",

note = "Funding Information: Received March 26,1976,f rom the Department of Chemistry, University College, Galway, Ireland. Accepted for publication August 3,1976. The authors thank the Department of Education (Ireland) for a grant to G. A. Benson. To whom inquiries should be directed.",

year = "1977",

month = jun,

doi = "10.1002/jps.2600660642",

language = "English (US)",

volume = "66",

pages = "883--884",

journal = "Journal of pharmaceutical sciences",

issn = "0022-3549",

publisher = "Elsevier B.V.",

number = "6",

}

TY - JOUR

T1 - Cytotoxic agents from Michelia champaca and Talauma ovata

T2 - Parthenolide and costunolide

AU - Hoffmann, Joseph J.

AU - Torrance, Sterling J.

AU - Wiedhopf, Richard M.

AU - Cole, Jack R.

N1 - Funding Information: Received March 26,1976,f rom the Department of Chemistry, University College, Galway, Ireland. Accepted for publication August 3,1976. The authors thank the Department of Education (Ireland) for a grant to G. A. Benson. To whom inquiries should be directed.

PY - 1977/6

Y1 - 1977/6

N2 - The ethanol extract of Michelia champaca and the petroleum ether extract of Talauma ovata showed activity toward the human epidermoid carcinoma of the nasopharynx test system. The active constituents were sesquiterpene lactones, identified as parthenolide (C15H20O3) and costunolide (C15H20O2). Their identities were proven by elemental analyses, PMR, IR, and mass spectral data, melting‐point and mixed melting‐point determinations, and comparisons with authentic samples and spectra.

AB - The ethanol extract of Michelia champaca and the petroleum ether extract of Talauma ovata showed activity toward the human epidermoid carcinoma of the nasopharynx test system. The active constituents were sesquiterpene lactones, identified as parthenolide (C15H20O3) and costunolide (C15H20O2). Their identities were proven by elemental analyses, PMR, IR, and mass spectral data, melting‐point and mixed melting‐point determinations, and comparisons with authentic samples and spectra.

KW - Costunolide—isolated from ethanol extract of bark of Michelia champaca and petroleum ether extract of roots of Talauma ovata, cytotoxic activity evaluated

KW - Cytotoxic activity—plant constituents parthenolide and costunolide evaluated

KW - Michelia champaca—parthenolide and costunolide isolated from ethanol extract of bark, cytotoxic activity evaluated

KW - Parthenolide—isolated from ethanol extract of bark of Michelia champaca, cytotoxic activity evaluated

KW - Talauma ovata—costunolide isolated from petroleum ether extract of roots, cytotoxic activity evaluated

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ER -

Cytotoxic agents from Michelia champaca and Talauma ovata: Parthenolide and costunolide

Abstract

Keywords

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