Cytotoxic activity of the titanium alkoxide (OPy) 2Ti(4AP) 2 against cancer colony forming cells

Elizabeth A. Williamson; Timothy J. Boyle; Rebecca Raymond; Jacqueline Farrington; Claire Verschraegen; Montaser Shaheen; Robert Hromas

doi:10.1007/s10637-010-9530-3

Cytotoxic activity of the titanium alkoxide (OPy) ₂Ti(4AP) ₂ against cancer colony forming cells

Elizabeth A. Williamson
, Timothy J. Boyle
, Rebecca Raymond
, Jacqueline Farrington
, Claire Verschraegen
, Montaser Shaheen
, Robert Hromas

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

A novel family of titanium alkoxides with two stable pyridinemethoxide moieties bound to a titanium metal center were synthesized and tested for cytotoxic activity on a variety of cancer cell lines using colony formation assays. One compound, (OPy) ₂Ti(4AP) ₂, where OPy is NC ₅H ₅CH ₂O-, and 4AP is 4-aminophenoxide (-OC ₆H ₅(NH ₂)-4), demonstrated increased cytotoxicity in breast, colon, and pancreatic cancer cell lines at 100 nanomolar levels with only short exposures. Further, (OPy) ₂Ti(4AP) ₂ had activity in colon and pancreatic cancer cell lines that are usually resistant to chemotherapy. This demonstrates that these novel titanium compounds may have a role in anti-cancer therapy, similar to platinum-based compounds, and the (OPy) ₂Ti(4AP) ₂ compound specifically deserves further investigation as an anticancer agent in chemo-resistant solid tumors.

Original language	English (US)
Pages (from-to)	114-120
Number of pages	7
Journal	Investigational New Drugs
Volume	30
Issue number	1
DOIs	https://doi.org/10.1007/s10637-010-9530-3
State	Published - Feb 2012
Externally published	Yes

Keywords

Colon cancer
Colony forming cell
Lung cancer
Pancreatic cancer
Titanium alkoxides

ASJC Scopus subject areas

Oncology
Pharmacology
Pharmacology (medical)

Access to Document

10.1007/s10637-010-9530-3

Cite this

@article{474c91fd38ba4acd917d1a0db93e5ad8,

title = "Cytotoxic activity of the titanium alkoxide (OPy) 2Ti(4AP) 2 against cancer colony forming cells",

abstract = "A novel family of titanium alkoxides with two stable pyridinemethoxide moieties bound to a titanium metal center were synthesized and tested for cytotoxic activity on a variety of cancer cell lines using colony formation assays. One compound, (OPy) 2Ti(4AP) 2, where OPy is NC 5H 5CH 2O-, and 4AP is 4-aminophenoxide (-OC 6H 5(NH 2)-4), demonstrated increased cytotoxicity in breast, colon, and pancreatic cancer cell lines at 100 nanomolar levels with only short exposures. Further, (OPy) 2Ti(4AP) 2 had activity in colon and pancreatic cancer cell lines that are usually resistant to chemotherapy. This demonstrates that these novel titanium compounds may have a role in anti-cancer therapy, similar to platinum-based compounds, and the (OPy) 2Ti(4AP) 2 compound specifically deserves further investigation as an anticancer agent in chemo-resistant solid tumors.",

keywords = "Colon cancer, Colony forming cell, Lung cancer, Pancreatic cancer, Titanium alkoxides",

author = "Williamson, \{Elizabeth A.\} and Boyle, \{Timothy J.\} and Rebecca Raymond and Jacqueline Farrington and Claire Verschraegen and Montaser Shaheen and Robert Hromas",

note = "Funding Information: Acknowledgements RH was supported by LLS 7388-06, NIH CA139429, NIH CA100862, NIH CA140442, and NIH HL075783. The authors also thank the U.S. Department of Energy, Office of Basic Energy Sciences, Division of Materials Sciences under Contract DE-AC04-94AL85000. Sandia is a multiprogramming laboratory operated by Sandia Corporation, a Lockheed Martin Company, for the United States Department of Energy",

year = "2012",

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doi = "10.1007/s10637-010-9530-3",

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pages = "114--120",

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T1 - Cytotoxic activity of the titanium alkoxide (OPy) 2Ti(4AP) 2 against cancer colony forming cells

AU - Williamson, Elizabeth A.

AU - Boyle, Timothy J.

AU - Raymond, Rebecca

AU - Farrington, Jacqueline

AU - Verschraegen, Claire

AU - Shaheen, Montaser

AU - Hromas, Robert

N1 - Funding Information: Acknowledgements RH was supported by LLS 7388-06, NIH CA139429, NIH CA100862, NIH CA140442, and NIH HL075783. The authors also thank the U.S. Department of Energy, Office of Basic Energy Sciences, Division of Materials Sciences under Contract DE-AC04-94AL85000. Sandia is a multiprogramming laboratory operated by Sandia Corporation, a Lockheed Martin Company, for the United States Department of Energy

PY - 2012/2

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N2 - A novel family of titanium alkoxides with two stable pyridinemethoxide moieties bound to a titanium metal center were synthesized and tested for cytotoxic activity on a variety of cancer cell lines using colony formation assays. One compound, (OPy) 2Ti(4AP) 2, where OPy is NC 5H 5CH 2O-, and 4AP is 4-aminophenoxide (-OC 6H 5(NH 2)-4), demonstrated increased cytotoxicity in breast, colon, and pancreatic cancer cell lines at 100 nanomolar levels with only short exposures. Further, (OPy) 2Ti(4AP) 2 had activity in colon and pancreatic cancer cell lines that are usually resistant to chemotherapy. This demonstrates that these novel titanium compounds may have a role in anti-cancer therapy, similar to platinum-based compounds, and the (OPy) 2Ti(4AP) 2 compound specifically deserves further investigation as an anticancer agent in chemo-resistant solid tumors.

AB - A novel family of titanium alkoxides with two stable pyridinemethoxide moieties bound to a titanium metal center were synthesized and tested for cytotoxic activity on a variety of cancer cell lines using colony formation assays. One compound, (OPy) 2Ti(4AP) 2, where OPy is NC 5H 5CH 2O-, and 4AP is 4-aminophenoxide (-OC 6H 5(NH 2)-4), demonstrated increased cytotoxicity in breast, colon, and pancreatic cancer cell lines at 100 nanomolar levels with only short exposures. Further, (OPy) 2Ti(4AP) 2 had activity in colon and pancreatic cancer cell lines that are usually resistant to chemotherapy. This demonstrates that these novel titanium compounds may have a role in anti-cancer therapy, similar to platinum-based compounds, and the (OPy) 2Ti(4AP) 2 compound specifically deserves further investigation as an anticancer agent in chemo-resistant solid tumors.

KW - Colon cancer

KW - Colony forming cell

KW - Lung cancer

KW - Pancreatic cancer

KW - Titanium alkoxides

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