Cytoskeletal conformational automata: Intra-neuronal support of neural networks

Stuart Hameroff; Judith Dayhoff; Djuro Koruga

doi:10.1109/ICSMC.1992.271797

Cytoskeletal conformational automata: Intra-neuronal support of neural networks

Stuart Hameroff, Judith Dayhoff, Djuro Koruga

Anesthesiology

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

The cytoskeleton, a lattice polymer network supporting shape and internal communication within living cells, may compute at the molecular level. We propose a set of models for computing within cytoskeletal filamentous polymers: microtubules ("MTs"), actin, intermediate filaments and cross-bridging microtubule-associated proteins ("MAPs"). Signals and information may be represented and transmitted via propagated conformational changes of these structures' subunits which locally interact via "cellular automata-like" interactions. Conformational automata (based on dipole-coupled coherent 10″ to 10′ sec cytoskeletal subunit excitations) may recognize and adapt to neuronal membrane and synaptic events (via second messenger systems) by changing conformational automata patterns, modifying MAP-MT connections (and thus neural architecture and synaptic function) and retrograde signaling. These cytoskeletal functions may subserve dendritic processing, ANN-like paradigms such as back-error propagation and provide a primary medium for neuronal information processing and storage.

Original language	English (US)
Title of host publication	1992 IEEE International Conference on Systems, Man, and Cybernetics
Subtitle of host publication	Emergent Innovations in Information Transfer Processing and Decision Making, SMC 1992
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	84-88
Number of pages	5
ISBN (Electronic)	0780307208, 9780780307209
DOIs	https://doi.org/10.1109/ICSMC.1992.271797
State	Published - 1992
Event	IEEE International Conference on Systems, Man, and Cybernetics, SMC 1992 - Chicago, United States Duration: Oct 18 1992 → Oct 21 1992

Publication series

Name	Conference Proceedings - IEEE International Conference on Systems, Man and Cybernetics
Volume	1992-January
ISSN (Print)	1062-922X

Other

Other	IEEE International Conference on Systems, Man, and Cybernetics, SMC 1992
Country/Territory	United States
City	Chicago
Period	10/18/92 → 10/21/92

ASJC Scopus subject areas

Electrical and Electronic Engineering
Control and Systems Engineering
Human-Computer Interaction

Access to Document

10.1109/ICSMC.1992.271797

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Hameroff, S., Dayhoff, J., & Koruga, D. (1992). Cytoskeletal conformational automata: Intra-neuronal support of neural networks. In 1992 IEEE International Conference on Systems, Man, and Cybernetics: Emergent Innovations in Information Transfer Processing and Decision Making, SMC 1992 (pp. 84-88). Article 271797 (Conference Proceedings - IEEE International Conference on Systems, Man and Cybernetics; Vol. 1992-January). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/ICSMC.1992.271797

Cytoskeletal conformational automata: Intra-neuronal support of neural networks. / Hameroff, Stuart; Dayhoff, Judith; Koruga, Djuro.
1992 IEEE International Conference on Systems, Man, and Cybernetics: Emergent Innovations in Information Transfer Processing and Decision Making, SMC 1992. Institute of Electrical and Electronics Engineers Inc., 1992. p. 84-88 271797 (Conference Proceedings - IEEE International Conference on Systems, Man and Cybernetics; Vol. 1992-January).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Hameroff, S, Dayhoff, J & Koruga, D 1992, Cytoskeletal conformational automata: Intra-neuronal support of neural networks. in 1992 IEEE International Conference on Systems, Man, and Cybernetics: Emergent Innovations in Information Transfer Processing and Decision Making, SMC 1992., 271797, Conference Proceedings - IEEE International Conference on Systems, Man and Cybernetics, vol. 1992-January, Institute of Electrical and Electronics Engineers Inc., pp. 84-88, IEEE International Conference on Systems, Man, and Cybernetics, SMC 1992, Chicago, United States, 10/18/92. https://doi.org/10.1109/ICSMC.1992.271797

Hameroff S, Dayhoff J, Koruga D. Cytoskeletal conformational automata: Intra-neuronal support of neural networks. In 1992 IEEE International Conference on Systems, Man, and Cybernetics: Emergent Innovations in Information Transfer Processing and Decision Making, SMC 1992. Institute of Electrical and Electronics Engineers Inc. 1992. p. 84-88. 271797. (Conference Proceedings - IEEE International Conference on Systems, Man and Cybernetics). doi: 10.1109/ICSMC.1992.271797

Hameroff, Stuart ; Dayhoff, Judith ; Koruga, Djuro. / Cytoskeletal conformational automata : Intra-neuronal support of neural networks. 1992 IEEE International Conference on Systems, Man, and Cybernetics: Emergent Innovations in Information Transfer Processing and Decision Making, SMC 1992. Institute of Electrical and Electronics Engineers Inc., 1992. pp. 84-88 (Conference Proceedings - IEEE International Conference on Systems, Man and Cybernetics).

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Cytoskeletal conformational automata: Intra-neuronal support of neural networks

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