TY - JOUR
T1 - Cytomegalovirus (CMV) research in immune senescence comes of age
T2 - overview of the 6th International Workshop on CMV and Immunosenescence
AU - Nikolich-Žugich, Janko
AU - van Lier, René A.W.
N1 - Funding Information:
Authors acknowledge all workshop participants, who have contributed substantially to ideas in this manuscript. J. N-Z was supported by the award AG048021 from the National Institute on Aging, NIH, and by the Bowman Professorship in Medical Sciences.
Publisher Copyright:
© 2017, American Aging Association.
PY - 2017/6/1
Y1 - 2017/6/1
N2 - Cytomegalovirus (CMV) is one of the most complex and most ubiquitous latent persistent viruses, with a considerable ability to evade and manipulate the immune system. Following an early-life infection, most immunocompetent humans spend several decades living with CMV, and, because the virus in these hosts does not cause manifest disease, CMV can be considered part of normal aging for more than half of humanity. However, there is accumulating evidence that CMV carriage is not a null event and that both potentially harmful and potentially beneficial outcomes emanate from the interaction of CMV with its mammalian hosts. This article provides an overview of the 6th International Workshop on CMV and Immunosenescence, highlighting the advances in the field made in the past two years, as related to CMV epidemiology/geroscience, CMV virology with an accent on latency, and CMV immune evasion and immune recognition of the virus and its antigens.
AB - Cytomegalovirus (CMV) is one of the most complex and most ubiquitous latent persistent viruses, with a considerable ability to evade and manipulate the immune system. Following an early-life infection, most immunocompetent humans spend several decades living with CMV, and, because the virus in these hosts does not cause manifest disease, CMV can be considered part of normal aging for more than half of humanity. However, there is accumulating evidence that CMV carriage is not a null event and that both potentially harmful and potentially beneficial outcomes emanate from the interaction of CMV with its mammalian hosts. This article provides an overview of the 6th International Workshop on CMV and Immunosenescence, highlighting the advances in the field made in the past two years, as related to CMV epidemiology/geroscience, CMV virology with an accent on latency, and CMV immune evasion and immune recognition of the virus and its antigens.
KW - Cytomegalovirus
KW - Immunosenescence
KW - Inflammation
KW - T cells
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U2 - 10.1007/s11357-017-9984-8
DO - 10.1007/s11357-017-9984-8
M3 - Editorial
C2 - 28624867
AN - SCOPUS:85020514835
SN - 2509-2715
VL - 39
SP - 245
EP - 249
JO - GeroScience
JF - GeroScience
IS - 3
ER -