Cytogenetics of bone marrow fibroblastic cells in idiopathic chronic myelofibrosis

B. R. Greenberg, L. Woo, I. C. Veomett, C. M. Payne, F. R. Ahmann

Research output: Contribution to journalArticlepeer-review

42 Scopus citations


To determine the nature of the fibroblastic proliferation in myelofibrosis, we studied the cytogenetic composition of a pure population of in-vitro bone marrow fibroblastic cells (FC) from a patient with idiopathic chronic myelofibrosis who had trisomy 8 in her unstimulated peripheral blood cells. This cytogenic abnormality was absent in all the FC studied supporting the premise that in the myeloproliferative disorders the myelofibrosis represents a secondary or non-neoplastic reaction to the clonal proliferation of haematopoietic stem cells.

Original languageEnglish (US)
Pages (from-to)487-490
Number of pages4
JournalBritish Journal of Haematology
Issue number4
StatePublished - 1987
Externally publishedYes

ASJC Scopus subject areas

  • Hematology


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