Cystic brain stem necrosis in a premature infant after prolonged bradycardia

J. Pindur, D. M. Capin, M. I. Johnson, N. E. Rance

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


A case is described of symmetrical cavitating brain stem necrosis produced by cardiac arrest in a premature infant. Two months after birth this 25-week gestational age infant suffered a prolonged episode of bradycardia. She was resuscitated and then died 3 weeks later. The autopsy revealed striking bilateral cavitation of the brain stem tegmentum extending in a columnar fashion from the upper portion of the spinal cord to the hypothalamus. The findings in this case are identical to the brain stem injury experimentally produced by complete cardiac arrest in the rhesus monkey.

Original languageEnglish (US)
Pages (from-to)667-669
Number of pages3
JournalActa Neuropathologica
Issue number6
StatePublished - May 1992


  • Bradycardia
  • Cardiac arrest
  • Hypoxic encephalopathy

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Clinical Neurology
  • Cellular and Molecular Neuroscience


Dive into the research topics of 'Cystic brain stem necrosis in a premature infant after prolonged bradycardia'. Together they form a unique fingerprint.

Cite this