Cyclosporine A modulation of Ca++ activated K+ channels in cardiac sensory afferent neurons

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5 Scopus citations


Whole-cell and single channel recordings were used to characterize the effects of the immunosuppressant cyclosporine A (CsA) on cardiac sensory neurons (CSN) of the nodose ganglia. Application of 10 nM CsA resulted in a 29.1% decrease in CSN input resistance and an average -8 ± 3 mV hyperpolarization of membrane potential. Application of 10 nM CsA had no effect on evoke Ca++ currents but increased evoked K+ currents by 158.9 ± 24%. Application of 10 nM CsA significantly increased the open probability of KCa channels by 183 ± 9%. These results suggest that application of CsA results in the activation of KCa channels in cardiac sensory neurons and this effect may contribute to the cellular mechanisms underlying CsA modulation of vagal afferent neurons.

Original languageEnglish (US)
Pages (from-to)243-247
Number of pages5
JournalBrain Research
Issue number1-2
StatePublished - Mar 9 1998


  • Calcium channels
  • Cyclosporine
  • Patch-clamp
  • Potassium channels
  • Vagal afferents

ASJC Scopus subject areas

  • General Neuroscience
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology


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