CYCLOPHOSPHAMIDE AND HUMAN ORGAN TRANSPLANTATION

T. E. Starzl; I. Penn; G. Schroter; C. W. Putnam; C. G. Halgrimson; G. Martineau; H. Amemiya; C. G. Groth

doi:10.1016/S0140-6736(71)92046-0

CYCLOPHOSPHAMIDE AND HUMAN ORGAN TRANSPLANTATION

T. E. Starzl
, I. Penn
, G. Schroter
, C. W. Putnam
, C. G. Halgrimson
, G. Martineau
, H. Amemiya
, C. G. Groth

Research output: Contribution to journal › Article › peer-review

46 Scopus citations

Abstract

Cyclophosphamide, a drug that has not previously had an important role in whole-organ transplantation, was given as a primary immunosuppressant to one liver and eleven kidney recipients, in combination with prednisone and horse antilymphocyte globulin. One of the patients died despite good renal-graft function. Two kidneys from a common cadaveric donor failed. The other nine patients have excellent function of their homografts after 2-3 months. Cyclophosphamide was substituted for azathioprine in one hepatic and five renal recipients who were suspected of having liver toxicity from azathioprine 3 months to almost 8 years post-transplantation. Graft function was maintained after this change, and the evidence of liver injury subsided.

Original language	English (US)
Pages (from-to)	70-74
Number of pages	5
Journal	The Lancet
Volume	298
Issue number	7715
DOIs	https://doi.org/10.1016/S0140-6736(71)92046-0
State	Published - Jul 10 1971
Externally published	Yes

ASJC Scopus subject areas

General Medicine

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10.1016/S0140-6736(71)92046-0

Cite this

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title = "CYCLOPHOSPHAMIDE AND HUMAN ORGAN TRANSPLANTATION",

abstract = "Cyclophosphamide, a drug that has not previously had an important role in whole-organ transplantation, was given as a primary immunosuppressant to one liver and eleven kidney recipients, in combination with prednisone and horse antilymphocyte globulin. One of the patients died despite good renal-graft function. Two kidneys from a common cadaveric donor failed. The other nine patients have excellent function of their homografts after 2-3 months. Cyclophosphamide was substituted for azathioprine in one hepatic and five renal recipients who were suspected of having liver toxicity from azathioprine 3 months to almost 8 years post-transplantation. Graft function was maintained after this change, and the evidence of liver injury subsided.",

author = "Starzl, \{T. E.\} and I. Penn and G. Schroter and Putnam, \{C. W.\} and Halgrimson, \{C. G.\} and G. Martineau and H. Amemiya and Groth, \{C. G.\}",

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T1 - CYCLOPHOSPHAMIDE AND HUMAN ORGAN TRANSPLANTATION

AU - Starzl, T. E.

AU - Penn, I.

AU - Schroter, G.

AU - Putnam, C. W.

AU - Halgrimson, C. G.

AU - Martineau, G.

AU - Amemiya, H.

AU - Groth, C. G.

PY - 1971/7/10

Y1 - 1971/7/10

N2 - Cyclophosphamide, a drug that has not previously had an important role in whole-organ transplantation, was given as a primary immunosuppressant to one liver and eleven kidney recipients, in combination with prednisone and horse antilymphocyte globulin. One of the patients died despite good renal-graft function. Two kidneys from a common cadaveric donor failed. The other nine patients have excellent function of their homografts after 2-3 months. Cyclophosphamide was substituted for azathioprine in one hepatic and five renal recipients who were suspected of having liver toxicity from azathioprine 3 months to almost 8 years post-transplantation. Graft function was maintained after this change, and the evidence of liver injury subsided.

AB - Cyclophosphamide, a drug that has not previously had an important role in whole-organ transplantation, was given as a primary immunosuppressant to one liver and eleven kidney recipients, in combination with prednisone and horse antilymphocyte globulin. One of the patients died despite good renal-graft function. Two kidneys from a common cadaveric donor failed. The other nine patients have excellent function of their homografts after 2-3 months. Cyclophosphamide was substituted for azathioprine in one hepatic and five renal recipients who were suspected of having liver toxicity from azathioprine 3 months to almost 8 years post-transplantation. Graft function was maintained after this change, and the evidence of liver injury subsided.

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DO - 10.1016/S0140-6736(71)92046-0

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SP - 70

EP - 74

JO - The Lancet

JF - The Lancet

IS - 7715

ER -

CYCLOPHOSPHAMIDE AND HUMAN ORGAN TRANSPLANTATION

Abstract

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