CYCLOPHOSPHAMIDE AND HUMAN ORGAN TRANSPLANTATION

T. E. Starzl; I. Penn; G. Schroter; C. W. Putnam; C. G. Halgrimson; G. Martineau; H. Amemiya; C. G. Groth

doi:10.1016/S0140-6736(71)92046-0

CYCLOPHOSPHAMIDE AND HUMAN ORGAN TRANSPLANTATION

T. E. Starzl, I. Penn, G. Schroter, C. W. Putnam, C. G. Halgrimson, G. Martineau, H. Amemiya, C. G. Groth

Research output: Contribution to journal › Article › peer-review

46 Scopus citations

Abstract

Cyclophosphamide, a drug that has not previously had an important role in whole-organ transplantation, was given as a primary immunosuppressant to one liver and eleven kidney recipients, in combination with prednisone and horse antilymphocyte globulin. One of the patients died despite good renal-graft function. Two kidneys from a common cadaveric donor failed. The other nine patients have excellent function of their homografts after 2-3 months. Cyclophosphamide was substituted for azathioprine in one hepatic and five renal recipients who were suspected of having liver toxicity from azathioprine 3 months to almost 8 years post-transplantation. Graft function was maintained after this change, and the evidence of liver injury subsided.

Original language	English (US)
Pages (from-to)	70-74
Number of pages	5
Journal	The Lancet
Volume	298
Issue number	7715
DOIs	https://doi.org/10.1016/S0140-6736(71)92046-0
State	Published - Jul 10 1971
Externally published	Yes

ASJC Scopus subject areas

General Medicine

Access to Document

10.1016/S0140-6736(71)92046-0

Cite this

@article{46e95d7cb8b4475982d394b4925bba30,

title = "CYCLOPHOSPHAMIDE AND HUMAN ORGAN TRANSPLANTATION",

abstract = "Cyclophosphamide, a drug that has not previously had an important role in whole-organ transplantation, was given as a primary immunosuppressant to one liver and eleven kidney recipients, in combination with prednisone and horse antilymphocyte globulin. One of the patients died despite good renal-graft function. Two kidneys from a common cadaveric donor failed. The other nine patients have excellent function of their homografts after 2-3 months. Cyclophosphamide was substituted for azathioprine in one hepatic and five renal recipients who were suspected of having liver toxicity from azathioprine 3 months to almost 8 years post-transplantation. Graft function was maintained after this change, and the evidence of liver injury subsided.",

author = "Starzl, {T. E.} and I. Penn and G. Schroter and Putnam, {C. W.} and Halgrimson, {C. G.} and G. Martineau and H. Amemiya and Groth, {C. G.}",

year = "1971",

month = jul,

day = "10",

doi = "10.1016/S0140-6736(71)92046-0",

language = "English (US)",

volume = "298",

pages = "70--74",

journal = "The Lancet",

issn = "0140-6736",

publisher = "Elsevier B.V.",

number = "7715",

}

TY - JOUR

T1 - CYCLOPHOSPHAMIDE AND HUMAN ORGAN TRANSPLANTATION

AU - Starzl, T. E.

AU - Penn, I.

AU - Schroter, G.

AU - Putnam, C. W.

AU - Halgrimson, C. G.

AU - Martineau, G.

AU - Amemiya, H.

AU - Groth, C. G.

PY - 1971/7/10

Y1 - 1971/7/10

N2 - Cyclophosphamide, a drug that has not previously had an important role in whole-organ transplantation, was given as a primary immunosuppressant to one liver and eleven kidney recipients, in combination with prednisone and horse antilymphocyte globulin. One of the patients died despite good renal-graft function. Two kidneys from a common cadaveric donor failed. The other nine patients have excellent function of their homografts after 2-3 months. Cyclophosphamide was substituted for azathioprine in one hepatic and five renal recipients who were suspected of having liver toxicity from azathioprine 3 months to almost 8 years post-transplantation. Graft function was maintained after this change, and the evidence of liver injury subsided.

AB - Cyclophosphamide, a drug that has not previously had an important role in whole-organ transplantation, was given as a primary immunosuppressant to one liver and eleven kidney recipients, in combination with prednisone and horse antilymphocyte globulin. One of the patients died despite good renal-graft function. Two kidneys from a common cadaveric donor failed. The other nine patients have excellent function of their homografts after 2-3 months. Cyclophosphamide was substituted for azathioprine in one hepatic and five renal recipients who were suspected of having liver toxicity from azathioprine 3 months to almost 8 years post-transplantation. Graft function was maintained after this change, and the evidence of liver injury subsided.

UR - http://www.scopus.com/inward/record.url?scp=0015218229&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0015218229&partnerID=8YFLogxK

U2 - 10.1016/S0140-6736(71)92046-0

DO - 10.1016/S0140-6736(71)92046-0

M3 - Article

C2 - 4103984

AN - SCOPUS:0015218229

SN - 0140-6736

VL - 298

SP - 70

EP - 74

JO - The Lancet

JF - The Lancet

IS - 7715

ER -

CYCLOPHOSPHAMIDE AND HUMAN ORGAN TRANSPLANTATION

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this