TY - JOUR
T1 - Cutaneous malignant melanoma (arizona cancer center experience). I. Natural history and prognostic factors influencing survival in patients with stage i disease
AU - Meyskens, Frank L.
AU - Berdeaux, Donald H.
AU - Parks, Bruce
AU - Tong, Tony
AU - Loescher, Lois
AU - Moon, Thomas E.
PY - 1988/9/15
Y1 - 1988/9/15
N2 - The authors have studied the natural history of 377 patients with Stage I cutaneous malignant melanoma followed at the Arizona Cancer Center, Tucson. Two hundred eight patients, or 55%, remained free of metastatic disease after a median follow‐up of 30 months. The survival at 5,8, and 10 years was 69, 65, and 63%, respectively. Natural breakpoints in Breslow thickness for survival occurred at 0.85, 1.95, and 4.00 mm. These are not significantly different from those found by other investigators. A step‐down multivariate analysis using the Cox regression model yielded four factors as highly significant in predicting survival: Breslow thickness (P < 0.001), an age/sex interaction (P = 0.0012), clinical ulceration (P = 0.0039), and a prophylactic node dissection (P = 0.019). No predictive value for a BANS or non‐BANS location was detected. These results are discussed in reference to other large series which describe the natural history of cutaneous melanoma.
AB - The authors have studied the natural history of 377 patients with Stage I cutaneous malignant melanoma followed at the Arizona Cancer Center, Tucson. Two hundred eight patients, or 55%, remained free of metastatic disease after a median follow‐up of 30 months. The survival at 5,8, and 10 years was 69, 65, and 63%, respectively. Natural breakpoints in Breslow thickness for survival occurred at 0.85, 1.95, and 4.00 mm. These are not significantly different from those found by other investigators. A step‐down multivariate analysis using the Cox regression model yielded four factors as highly significant in predicting survival: Breslow thickness (P < 0.001), an age/sex interaction (P = 0.0012), clinical ulceration (P = 0.0039), and a prophylactic node dissection (P = 0.019). No predictive value for a BANS or non‐BANS location was detected. These results are discussed in reference to other large series which describe the natural history of cutaneous melanoma.
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U2 - 10.1002/1097-0142(19880915)62:6<1207::AID-CNCR2820620628>3.0.CO;2-A
DO - 10.1002/1097-0142(19880915)62:6<1207::AID-CNCR2820620628>3.0.CO;2-A
M3 - Article
C2 - 3409189
AN - SCOPUS:0023721812
SN - 0008-543X
VL - 62
SP - 1207
EP - 1214
JO - Cancer
JF - Cancer
IS - 6
ER -