Abstract
Livers from donors positive for antibody against anti-HBc can potentially transmit de novo hepatitis B (DNH) to their recipients. Despite a good outcome, prophylaxis is usually offered to such recipients. There is no consensus on the standard prophylactic regimen and hence prophylaxis varies among different transplant centres. Nonetheless, hepatitis B immune globulin (HBIG) is considered the mainstay of such prophylaxis, either alone or in combination with an oral antiviral treatment. We aim to provide a concise review of the current use of HBIG in prevention of DNH. We also address a few important questions regarding HBIG use.
Original language | English (US) |
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Pages (from-to) | 635-643 |
Number of pages | 9 |
Journal | Hepatology International |
Volume | 5 |
Issue number | 2 |
DOIs | |
State | Published - Jun 2011 |
Externally published | Yes |
Keywords
- De novo hepatitis B
- Hepatitis B immune globulin
- Liver transplant
- Prophylaxis
ASJC Scopus subject areas
- Hepatology