Cu-free click cycloaddition reactions in chemical biology

John C. Jewett; Carolyn R. Bertozzi

doi:10.1039/b901970g

Cu-free click cycloaddition reactions in chemical biology

John C. Jewett, Carolyn R. Bertozzi

Research output: Contribution to journal › Article › peer-review

1381 Scopus citations

Abstract

Bioorthogonal chemical reactions are paving the way for new innovations in biology. These reactions possess extreme selectivity and biocompatibility, such that their participating reagents can form covalent bonds within richly functionalized biological systems-in some cases, living organisms. This tutorial review will summarize the history of this emerging field, as well as recent progress in the development and application of bioorthogonal copper-free click cycloaddition reactions.

Original language	English (US)
Pages (from-to)	1272-1279
Number of pages	8
Journal	Chemical Society Reviews
Volume	39
Issue number	4
DOIs	https://doi.org/10.1039/b901970g
State	Published - Mar 22 2010
Externally published	Yes

ASJC Scopus subject areas

General Chemistry

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10.1039/b901970g

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abstract = "Bioorthogonal chemical reactions are paving the way for new innovations in biology. These reactions possess extreme selectivity and biocompatibility, such that their participating reagents can form covalent bonds within richly functionalized biological systems-in some cases, living organisms. This tutorial review will summarize the history of this emerging field, as well as recent progress in the development and application of bioorthogonal copper-free click cycloaddition reactions.",

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Cu-free click cycloaddition reactions in chemical biology

Abstract

ASJC Scopus subject areas

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