Cu-free click cycloaddition reactions in chemical biology

John C. Jewett, Carolyn R. Bertozzi

Research output: Contribution to journalArticlepeer-review

1320 Scopus citations


Bioorthogonal chemical reactions are paving the way for new innovations in biology. These reactions possess extreme selectivity and biocompatibility, such that their participating reagents can form covalent bonds within richly functionalized biological systems-in some cases, living organisms. This tutorial review will summarize the history of this emerging field, as well as recent progress in the development and application of bioorthogonal copper-free click cycloaddition reactions.

Original languageEnglish (US)
Pages (from-to)1272-1279
Number of pages8
JournalChemical Society Reviews
Issue number4
StatePublished - Mar 22 2010

ASJC Scopus subject areas

  • General Chemistry


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