CTR1, a negative regulator of the ethylene response pathway in arabidopsis, encodes a member of the Raf family of protein kinases

Joseph J. Kieber; Madge Rothenberg; Gregg Roman; Kenneth A. Feldmann; Joseph R. Ecker

doi:10.1016/0092-8674(93)90119-B

CTR1, a negative regulator of the ethylene response pathway in arabidopsis, encodes a member of the Raf family of protein kinases

Joseph J. Kieber, Madge Rothenberg, Gregg Roman, Kenneth A. Feldmann, Joseph R. Ecker

Plant Sciences, School of

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Abstract

We isolated a recessive Arabidopsis mutant, ctr1, that constitutively exhibits seedling and adult phenotypes observed in plants treated with the plant hormone ethylene. The ctr1 adult morphology can be phenocopied by treatment of wild-type plants with exogenous ethylene and is due, at least in part, to inhibition of cell elongation. Seedlings and adult ctr1 plants show constitutive expression of ethylene-regulated genes. The epistasis of ctr1 and other ethylene response mutants has defined the position of CTR1 in the ethylene signal transduction pathway. The CTR1 gene has been cloned, and the DNA sequences of four mutant alleles were determined. The gene encodes a putative serine/threonine protein kinase that is most closely related to the Raf protein kinase family.

Original language	English (US)
Pages (from-to)	427-441
Number of pages	15
Journal	Cell
Volume	72
Issue number	3
DOIs	https://doi.org/10.1016/0092-8674(93)90119-B
State	Published - Feb 12 1993

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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title = "CTR1, a negative regulator of the ethylene response pathway in arabidopsis, encodes a member of the Raf family of protein kinases",

abstract = "We isolated a recessive Arabidopsis mutant, ctr1, that constitutively exhibits seedling and adult phenotypes observed in plants treated with the plant hormone ethylene. The ctr1 adult morphology can be phenocopied by treatment of wild-type plants with exogenous ethylene and is due, at least in part, to inhibition of cell elongation. Seedlings and adult ctr1 plants show constitutive expression of ethylene-regulated genes. The epistasis of ctr1 and other ethylene response mutants has defined the position of CTR1 in the ethylene signal transduction pathway. The CTR1 gene has been cloned, and the DNA sequences of four mutant alleles were determined. The gene encodes a putative serine/threonine protein kinase that is most closely related to the Raf protein kinase family.",

author = "Kieber, {Joseph J.} and Madge Rothenberg and Gregg Roman and Feldmann, {Kenneth A.} and Ecker, {Joseph R.}",

note = "Funding Information: The authors gratefully acknowledge A. Theologis and K. Tatchell for critical review of the manuscript. We also thank P. Dunn for help with RI mapping. The Arabidopsis basicchitinase gene was kindly provided by D. Shah (Monsanto) and the rDNA gene and RFLP probes by E. Meyerowitz (California Institute of Technology). This work was supported in part by grants (GM R29 38820 and NSF IBN-92-05342) to J. R. E. and by an NSF Postdoctoral Fellowship in Plant Biology (DCB-9008323) to J. J. K.",

year = "1993",

month = feb,

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doi = "10.1016/0092-8674(93)90119-B",

language = "English (US)",

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pages = "427--441",

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T1 - CTR1, a negative regulator of the ethylene response pathway in arabidopsis, encodes a member of the Raf family of protein kinases

AU - Kieber, Joseph J.

AU - Rothenberg, Madge

AU - Roman, Gregg

AU - Feldmann, Kenneth A.

AU - Ecker, Joseph R.

N1 - Funding Information: The authors gratefully acknowledge A. Theologis and K. Tatchell for critical review of the manuscript. We also thank P. Dunn for help with RI mapping. The Arabidopsis basicchitinase gene was kindly provided by D. Shah (Monsanto) and the rDNA gene and RFLP probes by E. Meyerowitz (California Institute of Technology). This work was supported in part by grants (GM R29 38820 and NSF IBN-92-05342) to J. R. E. and by an NSF Postdoctoral Fellowship in Plant Biology (DCB-9008323) to J. J. K.

PY - 1993/2/12

Y1 - 1993/2/12

N2 - We isolated a recessive Arabidopsis mutant, ctr1, that constitutively exhibits seedling and adult phenotypes observed in plants treated with the plant hormone ethylene. The ctr1 adult morphology can be phenocopied by treatment of wild-type plants with exogenous ethylene and is due, at least in part, to inhibition of cell elongation. Seedlings and adult ctr1 plants show constitutive expression of ethylene-regulated genes. The epistasis of ctr1 and other ethylene response mutants has defined the position of CTR1 in the ethylene signal transduction pathway. The CTR1 gene has been cloned, and the DNA sequences of four mutant alleles were determined. The gene encodes a putative serine/threonine protein kinase that is most closely related to the Raf protein kinase family.

AB - We isolated a recessive Arabidopsis mutant, ctr1, that constitutively exhibits seedling and adult phenotypes observed in plants treated with the plant hormone ethylene. The ctr1 adult morphology can be phenocopied by treatment of wild-type plants with exogenous ethylene and is due, at least in part, to inhibition of cell elongation. Seedlings and adult ctr1 plants show constitutive expression of ethylene-regulated genes. The epistasis of ctr1 and other ethylene response mutants has defined the position of CTR1 in the ethylene signal transduction pathway. The CTR1 gene has been cloned, and the DNA sequences of four mutant alleles were determined. The gene encodes a putative serine/threonine protein kinase that is most closely related to the Raf protein kinase family.

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JO - Cell

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CTR1, a negative regulator of the ethylene response pathway in arabidopsis, encodes a member of the Raf family of protein kinases

Abstract

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