Crystal structure analysis of deamino-oxytocin: Conformational flexibility and receptor binding

S. P. Wood; I. J. Tickle; A. M. Treharne; J. E. Pitts; Y. Mascarenhas; J. Y. Li; J. Husain; S. Cooper; T. L. Blundell; V. J. Hruby; A. Buku; A. J. Fischman; H. R. Wyssbrod

doi:10.1126/science.3008332

Crystal structure analysis of deamino-oxytocin: Conformational flexibility and receptor binding

S. P. Wood, I. J. Tickle, A. M. Treharne, J. E. Pitts, Y. Mascarenhas, J. Y. Li, J. Husain, S. Cooper, T. L. Blundell, V. J. Hruby, A. Buku, A. J. Fischman, H. R. Wyssbrod

Chemistry and Biochemistry

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Abstract

Two crystal structures of deamino-oxytocin have been determined at better than 1.1 Å resolution from isomorphous replacement and anomalous scattering x-ray measurements. In each of two crystal forms there are two closely related conformers with disulfide bridges of different chirality, which may be important in receptor recognition and activation.

Original language	English (US)
Pages (from-to)	633-636
Number of pages	4
Journal	Science
Volume	232
Issue number	4750
DOIs	https://doi.org/10.1126/science.3008332
State	Published - 1986

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title = "Crystal structure analysis of deamino-oxytocin: Conformational flexibility and receptor binding",

abstract = "Two crystal structures of deamino-oxytocin have been determined at better than 1.1 {\AA} resolution from isomorphous replacement and anomalous scattering x-ray measurements. In each of two crystal forms there are two closely related conformers with disulfide bridges of different chirality, which may be important in receptor recognition and activation.",

author = "Wood, {S. P.} and Tickle, {I. J.} and Treharne, {A. M.} and Pitts, {J. E.} and Y. Mascarenhas and Li, {J. Y.} and J. Husain and S. Cooper and Blundell, {T. L.} and Hruby, {V. J.} and A. Buku and Fischman, {A. J.} and Wyssbrod, {H. R.}",

year = "1986",

doi = "10.1126/science.3008332",

language = "English (US)",

volume = "232",

pages = "633--636",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

number = "4750",

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TY - JOUR

T1 - Crystal structure analysis of deamino-oxytocin

T2 - Conformational flexibility and receptor binding

AU - Wood, S. P.

AU - Tickle, I. J.

AU - Treharne, A. M.

AU - Pitts, J. E.

AU - Mascarenhas, Y.

AU - Li, J. Y.

AU - Husain, J.

AU - Cooper, S.

AU - Blundell, T. L.

AU - Hruby, V. J.

AU - Buku, A.

AU - Fischman, A. J.

AU - Wyssbrod, H. R.

PY - 1986

Y1 - 1986

N2 - Two crystal structures of deamino-oxytocin have been determined at better than 1.1 Å resolution from isomorphous replacement and anomalous scattering x-ray measurements. In each of two crystal forms there are two closely related conformers with disulfide bridges of different chirality, which may be important in receptor recognition and activation.

AB - Two crystal structures of deamino-oxytocin have been determined at better than 1.1 Å resolution from isomorphous replacement and anomalous scattering x-ray measurements. In each of two crystal forms there are two closely related conformers with disulfide bridges of different chirality, which may be important in receptor recognition and activation.

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UR - http://www.scopus.com/inward/citedby.url?scp=0022444428&partnerID=8YFLogxK

U2 - 10.1126/science.3008332

DO - 10.1126/science.3008332

M3 - Article

C2 - 3008332

AN - SCOPUS:0022444428

VL - 232

SP - 633

EP - 636

JO - Science

JF - Science

SN - 0036-8075

IS - 4750

ER -

Crystal structure analysis of deamino-oxytocin: Conformational flexibility and receptor binding

Abstract

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