Crystal arthropathies and osteoarthritis—where is the link?

Mohamed Jarraya, Frank Roemer, C. Kent Kwoh, Ali Guermazi

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations


Osteoarthritis (OA) is one of the leading causes of disability worldwide. As our understanding of OA progressively has moved from a purely mechanical “wear and tear” concept toward a complex multi-tissue condition in which inflammation plays a central role, the possible role of crystal-induced inflammation in OA incidence and progression may be relevant. In addition to gout, which affects 4% of the US population, basic calcium phosphate and calcium pyrophosphate deposition both may induce joint inflammation and may play a role in pain in OA. This narrative review article discusses the possible mechanisms underlying the associations between crystal-induced arthropathies and OA, and the important implications of these for clinical practice and future research.

Original languageEnglish (US)
Pages (from-to)2037-2043
Number of pages7
JournalSkeletal Radiology
Issue number11
StatePublished - Nov 2023


  • Calcium pyrophosphate
  • Gout
  • Monosodium urate
  • Osteoarthritis

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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