Cryptosporidium species and subtypes and clinical manifestations in children, Peru

Vitaliano A. Cama, Caryn Bern, Jacqueline Roberts, Lilia Cabrera, Charles R. Sterling, Ynes Ortega, Robert H. Gilman, Lihua Xiao

    Research output: Contribution to journalArticlepeer-review

    232 Scopus citations


    To determine whether clinical manifestations are associated with genotypes or subtypes of Cryptosporidium spp., we studied a 4-year longitudinal birth cohort of 533 children in Peru. A total of 156 infection episodes were found in 109 children. Data from first infections showed that C. hominis was associated with diarrhea, nausea, vomiting, general malaise, and increased oocyst shedding intensity and duration. In contrast, C. parvum, C. meleagridis, C. canis, and C. felis were associated with diarrhea only. C. hominis subtype families were identified (Ia, Ib, Id, and Ie); all were associated with diarrhea. Ib was also associated with nausea, vomiting, and general malaise. All C. parvum specimens belonged to subtype family IIc. Analysis of risk factors did not show associations with specific Cryptosporidium spp. genotypes or subtypes. These findings strongly suggest that Cryptosporidium spp. and subtypes are linked to different clinical manifestations in children.

    Original languageEnglish (US)
    Pages (from-to)1567-1574
    Number of pages8
    JournalEmerging infectious diseases
    Issue number10
    StatePublished - Oct 2008

    ASJC Scopus subject areas

    • Epidemiology
    • Microbiology (medical)
    • Infectious Diseases


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