TY - JOUR
T1 - Cryptosporidium Enterocytozoon, and Cyclospora infections in pediatric and adult patients with diarrhea in Tanzania
AU - Cegielski, J. Peter
AU - Ortega, Ynes R.
AU - McKee, Scott
AU - Madden, John F.
AU - Gaido, Loretta
AU - Schwartz, David A.
AU - Manji, Karim
AU - Jorgensen, Anders F.
AU - Miller, Sara E.
AU - Pulipaka, Uma P.
AU - Msengi, Abel E.
AU - Mwakyusa, David H.
AU - Sterling, Charles R.
AU - Reller, L. Barth
PY - 1999
Y1 - 1999
N2 - Cryptosporidiosis, microsporidiosis, and cyclosporiasis were studied in four groups of Tanzanian inpatients: adults with AIDS-associated diarrhea, children with chronic diarrhea (of whom 23 of 59 were positive [+] for human immunodeficiency virus [HIV]), children with acute diarrhea (of whom 15 of 55 were HIV+), and HIV- control children without diarrhea. Cryptosporidium was identified in specimens from 6/86 adults, 5/59 children with chronic diarrhea (3/5, HIV+), 7/55 children with acute diarrhea (0/7, HIV+), and 0/20 control children. Among children with acute diarrhea, 7/7 with cryptosporidiosis were malnourished, compared with 10/48 without cryptosporidiosis (P < .01). Enterocytozoon was identified in specimens from 3/86 adults, 2/59 children with chronic diarrhea (1 HIV+), 0/55 children with acute diarrhea, and 4/20 control children. All four controls were underweight (P < .01). Cyclospora was identified in specimens from one adult and one child with acute diarrhea (HIV-). Thus, Cryptosporidium was the most frequent and Cyclospora the least frequent pathogen identified. Cryptosporidium and Enterocytozoon were associated with malnutrition. Asymptomatic fecal shedding of Enterocytozoon in otherwise healthy, HIV- children has not been described previously.
AB - Cryptosporidiosis, microsporidiosis, and cyclosporiasis were studied in four groups of Tanzanian inpatients: adults with AIDS-associated diarrhea, children with chronic diarrhea (of whom 23 of 59 were positive [+] for human immunodeficiency virus [HIV]), children with acute diarrhea (of whom 15 of 55 were HIV+), and HIV- control children without diarrhea. Cryptosporidium was identified in specimens from 6/86 adults, 5/59 children with chronic diarrhea (3/5, HIV+), 7/55 children with acute diarrhea (0/7, HIV+), and 0/20 control children. Among children with acute diarrhea, 7/7 with cryptosporidiosis were malnourished, compared with 10/48 without cryptosporidiosis (P < .01). Enterocytozoon was identified in specimens from 3/86 adults, 2/59 children with chronic diarrhea (1 HIV+), 0/55 children with acute diarrhea, and 4/20 control children. All four controls were underweight (P < .01). Cyclospora was identified in specimens from one adult and one child with acute diarrhea (HIV-). Thus, Cryptosporidium was the most frequent and Cyclospora the least frequent pathogen identified. Cryptosporidium and Enterocytozoon were associated with malnutrition. Asymptomatic fecal shedding of Enterocytozoon in otherwise healthy, HIV- children has not been described previously.
UR - http://www.scopus.com/inward/record.url?scp=0033006062&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033006062&partnerID=8YFLogxK
U2 - 10.1086/515131
DO - 10.1086/515131
M3 - Article
C2 - 10064250
AN - SCOPUS:0033006062
SN - 1058-4838
VL - 28
SP - 314
EP - 321
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
IS - 2
ER -