TY - JOUR
T1 - Cross-sectional study of patient- and physician-collected cervical cytology and human papillomavirus
AU - Garcia, Francisco A
AU - Barker, Bel
AU - Santos, Carlos
AU - Brown, Elena Mendez
AU - Nuño, Thomas
AU - Giuliano, Anna
AU - Davis, John
N1 - Funding Information:
The Population Council, Latin America Office, provided seed funding for this study. Thin-layer liquid cytology collection materials were provided at no cost by Cytyc Corp. (Boxborough, Massachusetts). This study was partially supported by grants from the National Institutes of Health (no. CA82715) and the Health Resource Services Administration (no. 316210). BB’s participation was partially underwritten by a career development grant from the University of Arizona.
PY - 2003/8/1
Y1 - 2003/8/1
N2 - OBJECTIVE: To compare the performance of patient- and physician-obtained cytology and human papillomavirus (HPV) testing for the detection of high-grade cervical intraepithelial neoplasia. METHODS: A cross-sectional study was performed involving 334 women seen at three colposcopy clinics (Tucson, Arizona; Hermosillo, Mexico; and Lima, Peru). All women used a cytobrush to self-collect specimens for cervical cytology and HPV testing. Subjects subsequently underwent physician collection for cytology and HPV, followed by a complete colposcopic evaluation with directed biopsy. Cytology was processed using thin-layer technology, and HPV was determined using the polymerase chain reaction technique. Test performance characteristics were determined using the histopathologic diagnosis as the reference standard and designating high-grade cervical intraepithelial neoplasia as clinically significant disease for the purpose of the analysis. RESULTS: The sensitivity of patient-collected cytology was significantly lower (55.0%) and specificity was significantly better (84.1%) than those of physician-directed sampling (85.2% and 73.4%, respectively). Patient-collected HPV had significantly lower sensitivity (49.0%) than physician sampling (82.2%), although specificity did not significantly differ. CONCLUSION: Patient collection is a feasible although inferior alternative to physician-collected cervical cytology and HPV testing.
AB - OBJECTIVE: To compare the performance of patient- and physician-obtained cytology and human papillomavirus (HPV) testing for the detection of high-grade cervical intraepithelial neoplasia. METHODS: A cross-sectional study was performed involving 334 women seen at three colposcopy clinics (Tucson, Arizona; Hermosillo, Mexico; and Lima, Peru). All women used a cytobrush to self-collect specimens for cervical cytology and HPV testing. Subjects subsequently underwent physician collection for cytology and HPV, followed by a complete colposcopic evaluation with directed biopsy. Cytology was processed using thin-layer technology, and HPV was determined using the polymerase chain reaction technique. Test performance characteristics were determined using the histopathologic diagnosis as the reference standard and designating high-grade cervical intraepithelial neoplasia as clinically significant disease for the purpose of the analysis. RESULTS: The sensitivity of patient-collected cytology was significantly lower (55.0%) and specificity was significantly better (84.1%) than those of physician-directed sampling (85.2% and 73.4%, respectively). Patient-collected HPV had significantly lower sensitivity (49.0%) than physician sampling (82.2%), although specificity did not significantly differ. CONCLUSION: Patient collection is a feasible although inferior alternative to physician-collected cervical cytology and HPV testing.
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U2 - 10.1016/S0029-7844(03)00517-9
DO - 10.1016/S0029-7844(03)00517-9
M3 - Article
C2 - 12907098
AN - SCOPUS:0043198760
SN - 0029-7844
VL - 102
SP - 266
EP - 272
JO - Obstetrics and gynecology
JF - Obstetrics and gynecology
IS - 2
ER -