Cross-regulation of signaling pathways: An example of nuclear hormone receptors and the canonical Wnt pathway

Marcy E. Beildeck, Edward P. Gelmann, Stephen, W. Byers

Research output: Contribution to journalReview articlepeer-review

66 Scopus citations

Abstract

Predicting the potential physiological outcome(s) of any given molecular pathway is complex because of cross-talk with other pathways. This is particularly evident in the case of the nuclear hormone receptor and canonical Wnt pathways, which regulate cell growth and proliferation, differentiation, apoptosis, and metastatic potential in numerous tissues. These pathways are known to intersect at many levels: in the intracellular space, at the membrane, in the cytoplasm, and within the nucleus. The outcomes of these interactions are important in the control of stem cell differentiation and maintenance, feedback loops, and regulating oncogenic potential. The aim of this review is to demonstrate the importance of considering pathway cross-talk when predicting functional outcomes of signaling, using nuclear hormone receptor/canonical Wnt pathway cross-talk as an example.

Original languageEnglish (US)
Pages (from-to)1763-1772
Number of pages10
JournalExperimental Cell Research
Volume316
Issue number11
DOIs
StatePublished - Jul 2010
Externally publishedYes

Keywords

  • AR
  • Androgen receptor
  • Beta-catenin
  • Catenin
  • Cross-talk
  • Hormone
  • Nuclear hormone receptor
  • VDR
  • Vitamin D receptor

ASJC Scopus subject areas

  • Cell Biology

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