Critical review in oral biology and medicine: Sensitivity of salivary glands to radiation: From animal models to therapies

O. Grundmann; G. C. Mitchell; K. H. Limesand

doi:10.1177/0022034509343143

Critical review in oral biology and medicine: Sensitivity of salivary glands to radiation: From animal models to therapies

O. Grundmann, G. C. Mitchell, K. H. Limesand

Research output: Contribution to journal › Article › peer-review

193 Scopus citations

Abstract

Radiation therapy for head and neck cancer causes significant secondary side-effects in normal salivary glands, resulting in diminished quality of life for these individuals. Salivary glands are exquisitely sensitive to radiation and display acute and chronic responses to radiotherapy. This review will discuss clinical implications of radiosensitivity in normal salivary glands, compare animal models used to investigate radiation-induced salivary gland damage, address therapeutic advances, and project future directions in the field.

Original language	English (US)
Pages (from-to)	894-903
Number of pages	10
Journal	Journal of Dental Research
Volume	88
Issue number	10
DOIs	https://doi.org/10.1177/0022034509343143
State	Published - Oct 2009

Keywords

Animal models
Radiation
Salivary gland dysfunction
Salivary glands
Therapy
Xerostomia.

ASJC Scopus subject areas

General Dentistry

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10.1177/0022034509343143

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abstract = "Radiation therapy for head and neck cancer causes significant secondary side-effects in normal salivary glands, resulting in diminished quality of life for these individuals. Salivary glands are exquisitely sensitive to radiation and display acute and chronic responses to radiotherapy. This review will discuss clinical implications of radiosensitivity in normal salivary glands, compare animal models used to investigate radiation-induced salivary gland damage, address therapeutic advances, and project future directions in the field.",

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KW - Therapy

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Critical review in oral biology and medicine: Sensitivity of salivary glands to radiation: From animal models to therapies

Abstract

Keywords

ASJC Scopus subject areas

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